Methane Production in Patients with Cystic Fibrosis

Bujanover, Yoram; Peled, Yael; Blau, Hannah; Yahav, Jacob; Katzenelson, D; Gilat, Tuvia

doi:10.1097/00005176-198705000-00013

Cited by 13 publications

(8 citation statements)

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“…Our study lends evidence to this hypothesis . Although no studies have investigated by fecal culture the prevalence of methanogen colonization in normal children, our data and those of Bujanover et al in children with cystic fibrosis (10) suggest that, as in adults, many children may harbor methanogens but lack the necessary intracolonic factors to enable significant methane generation. Breath methane excretion has been suggested as a marker of colonic bacterial metabolism, as is present in patients who are at a greater risk than the general population for developing large-bowel cancer (7)(8)(9).…”

Section: Discussionsupporting

confidence: 39%

“…These include prolonged colonic transit time (4,5), elevated intracolonic pH (5,6), and excessively anaerobic intracolonic conditions (4). In addition, certain diseases of the colon, including carcinoma (7)(8)(9), polyposis (7), cystic fibrosis (10), and diverticulosis (11), have been associated with enhanced methane production. Of interest, patients with severe, aorto-ileac atherosclerotic disease have the highest prevalence of methane excretion reported in the literature, suggesting that colonic mucosal oxygenation may affect the bacterial population within the lumen (12).…”

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confidence: 99%

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Breath Methane Production in Children With Constipation and Encopresis

Fiedorek,

Pumphrey,

Casteel

1990

J. pediatr. gastroenterol. nutr.

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SummaryBreath methane excretion is uncommon in children compared with adults. Certain intracolonic conditions, however, have been associated with enhanced methane generation. We hypothesized that encopretic and constipated children, who have abnormal colonic transit times, more likely would excrete methane than healthy children. To determine the prevalence of methane excretion among children with encopresis or simple constipation, we performed breath methane analysis on such patients and age‐, race‐, and sex‐matched control subjects. Encopretic patients (mean age, 8.3 ± 3.0 years) had daily, involuntary passage of feces and clinical evidence of constipation. Constipated patients (mean age, 7.1 ± 2.9 years) had a history of hard stools and at least one of the following symptoms: infrequent defecation, dyschezia, hematochezia, difficult stool expulsion, or abdominal pain during bowel movements. Methane excretion was present in 26 of 40 (65%) encopretic patients versus 6 of 40 (15%) control patients (P < 0.001). In contrast, 3 of 27 (11%) constipated patients were methane excreters, versus 2 of 27 (7%) controls (P = 0.4). Fourteen asymptomatic encopretic patients were retested after successful therapy; eight were methane excreters initially, but five of eight did not excrete methane after treatment. We conclude that methane is produced in a large number of children with encopresis. Treatment appears to alter metha‐nogenesis in such patients. The prevalence of methane producers among constipated children is not different from the prevalence in healthy subjects. Methanogenesis in encopretic patients may be enhanced by prolonged colonic transit time or abnormal intracolonic conditions.

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Section: Discussionsupporting

confidence: 39%

mentioning

confidence: 99%

Breath Methane Production in Children With Constipation and Encopresis

Fiedorek,

Pumphrey,

Casteel

1990

J. pediatr. gastroenterol. nutr.

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“…[10][11][12][13] Methane production during the first 3 years of life is rare, but thereafter the percentage of methane producers increases progressively, almost attaining the adult rate by the age of 14 years. [15][16][17] Certain diseases, such as colonic carcinoma, 18-21 cystic fibrosis, 22 and diverticulosis, 18 have been associated with enhanced methane production. [15][16][17] Certain diseases, such as colonic carcinoma, 18-21 cystic fibrosis, 22 and diverticulosis, 18 have been associated with enhanced methane production.…”

mentioning

confidence: 99%

Breath Methane Associated With Slow Colonic Transit Time in Children With Chronic Constipation

Soares

Lederman²,

Fagundes-Neto³

et al. 2005

Journal of Clinical Gastroenterology

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“…Elevated concentrations of EBC sodium and chloride ions were shown in CF patients and correlated with disease severity and the sweat test (Balint et al, unpublished observation). The percentages of methane producers in CF patients are higher than in normal subjects, but there is no difference between methane producers and nonproducers with respect to the degree of malabsorption among CF patients [122]. Glucose-hydrogen breath test after an overnight fast more likely shows elevation of fasting exhaled hydrogen levels compared with controls suggesting a high prevalence of small bowel bacterial overgrowth in these patients [123].…”

Section: Exhaled Markers In Some Pulmonary Diseasesmentioning

confidence: 99%

Breath Tests in Respiratory and Critical Care Medicine: From Research to Practice in Current Perspectives

Cheepsattayakorn

2013

BioMed Research International

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Today, exhaled nitric oxide has been studied the most, and most researches have now focusd on asthma. More than a thousand different volatile organic compounds have been observed in low concentrations in normal human breath. Alkanes and methylalkanes, the majority of breath volatile organic compounds, have been increasingly used by physicians as a novel method to diagnose many diseases without discomforts of invasive procedures. None of the individual exhaled volatile organic compound alone is specific for disease. Exhaled breath analysis techniques may be available to diagnose and monitor the diseases in home setting when their sensitivity and specificity are improved in the future.

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Methane Production in Patients with Cystic Fibrosis

Cited by 13 publications

References 0 publications

Breath Methane Production in Children With Constipation and Encopresis

Breath Methane Production in Children With Constipation and Encopresis

Breath Methane Associated With Slow Colonic Transit Time in Children With Chronic Constipation

Breath Tests in Respiratory and Critical Care Medicine: From Research to Practice in Current Perspectives

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