Methanol Contamination of Romanian Home-Distilled Alcohol

Levy, Phillip D.; Hexdall, Aaron; Gordon, Peter E.; Boeriu, Cristian; Heller, Milton; Nelson, Lewis S.

doi:10.1081/clt-120018267

Cited by 31 publications

(24 citation statements)

References 10 publications

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“…The only study which found potentially toxic levels of methanol was done in Romania by Levy et al . . They analysed 35 samples of Tuica alcohol, a distilled alcohol from fruit.…”

Section: Discussionmentioning

confidence: 99%

Methanol content in homemade alcohol from a province in North Vietnam

Lao

Pham

et al. 2019

Drug and Alcohol Review

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Introduction and Aims. Methanol poisonings pose a major risk especially where illegal alcohol is consumed. The source of the methanol in the drinks are debated. We aimed to evaluate whether home distillation of alcohol made from rice was capable of producing toxic amounts of methanol. Design and Methods. Twenty households with homemade alcohol production in Phu Tho province in Vietnam were included in this pilot study. We followed the whole production process and an alcohol sample from each household was analysed for methanol content. Results. 17 (85%) of the samples contained detectable levels of methanol. The median concentration was 9 mg/L (range 2-37 mg/L). To develop clinical symptoms of methanol poisoning from the sample with the highest concentration would require drinking more than 424 L. Discussion and Conclusions. Homemade alcohol from rice did not contain sufficient amount of methanol to cause toxicity in our study. This supports the theory of methanol being added to ethanol post production for economical purposes as the main source of mass poisonings. [Lao Y, Pham BD, Le HT, Nguyen Van H, Hovda KE. Methanol content in homemade alcohol from a province in North Vietnam. Drug Alcohol Rev 2019;38:537-542]

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“…The only study which found potentially toxic levels of methanol was done in Romania by Levy et al . . They analysed 35 samples of Tuica alcohol, a distilled alcohol from fruit.…”

Section: Discussionmentioning

confidence: 99%

Methanol content in homemade alcohol from a province in North Vietnam

Lao

Pham

et al. 2019

Drug and Alcohol Review

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“…Of main interest for consumer's health is the amount of methanol, which is the second compound found in fruit distillates after ethanol. It is usually ingested by consumers in low doses, but can create serious problems especially in countries with high unrecorded alcohol consumption [1].…”

Section: Introductionmentioning

confidence: 99%

Advances in Distilled Beverages Authenticity and Quality Testing

Coldea¹,

Mudura²,

Socaciu³

2017

Ideas and Applications Toward Sample Preparation for Food and Beverage Analysis

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Given the advent of the consumers and producers demands, researches are focusing lately to develop innovative, cost-effective, progressively complex alcoholic beverages. As alcohol consumption has a heavy impact on social environment and health, fast and safe solutions for industrial application are needed. In this chapter, the recent advances in the field of alcoholic beverages authenticity and quality testing are summarised. Solutions for the online monitoring of the process of distilled beverages are offered and the recent methods for identification of raw material and process formed biomarkers of distilled beverages are presented.

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“…In outbreaks, methanol poisoning usually results from consumption of alcoholic beverages that have been spiked with methanol due to its low cost. These epidemics occur world‐wide, often with high mortality rates .…”

Section: Epidemiology Of Toxic Alcohol Ingestionsmentioning

confidence: 99%

Antidotes for poisoning by alcohols that form toxic metabolites

McMartin

Jacobsen

Hovda

2016

Brit J Clinical Pharma

110

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The alcohols, methanol, ethylene glycol and diethylene glycol, have many features in common, the most important of which is the fact that the compounds themselves are relatively non-toxic but are metabolized, initially by alcohol dehydrogenase, to various toxic intermediates. These compounds are readily available worldwide in commercial products as well as in homemade alcoholic beverages, both of which lead to most of the poisoning cases, from either unintentional or intentional ingestion. Although relatively infrequent in overall occurrence, poisonings by metabolically-toxic alcohols do unfortunately occur in outbreaks and can result in severe morbidity and mortality. These poisonings have traditionally been treated with ethanol since it competes for the active site of alcohol dehydrogenase and decreases the formation of toxic metabolites. Although ethanol can be effective in these poisonings, there are substantial practical problems with its use and so fomepizole, a potent competitive inhibitor of alcohol dehydrogenase, was developed for a hopefully better treatment for metabolically-toxic alcohol poisonings. Fomepizole has few side effects and is easy to use in practice and it may obviate the need for haemodialysis in some, but not all, patients. Hence, fomepizole has largely replaced ethanol as the toxic alcohol antidote in many countries. Nevertheless, ethanol remains an important alternative because access to fomepizole can be limited, the cost may appear excessive, or the physician may prefer ethanol due to experience.

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Methanol Contamination of Romanian Home-Distilled Alcohol

Cited by 31 publications

References 10 publications

Methanol content in homemade alcohol from a province in North Vietnam

Methanol content in homemade alcohol from a province in North Vietnam

Advances in Distilled Beverages Authenticity and Quality Testing

Antidotes for poisoning by alcohols that form toxic metabolites

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