2016
DOI: 10.3390/medicines3040026
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Methanol Extract from Anogeissus leiocarpus (DC) Guill. et Perr. (Combretaceae) Stem Bark Quenches the Quorum Sensing of Pseudomonas aeruginosa PAO1

Abstract: Background: Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, Pseudomonas aeruginosa is a threat particularly in immunocompromised patients. Considering the central role of quorum sensing in the production of virulence factors, inhibition of bacterial communication mechanism constitute an opportunity to attenuate pathogenicity of bacteria resistant to available antibiotics. Our study aimed to assess the anti-quorum sensing activity of Anogeissus leiocarpus, traditionally… Show more

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Cited by 16 publications
(15 citation statements)
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“…Combretaceae is a relatively small family with 10 genera and 530 species [15]. Extracts containing the flavonoids catechin and naringenin [37] from Combretum spp., ellagic acid derivatives from Terminalia chebula [38] and from Anogeissus leiocarpus [39] have been linked to inhibition of the QS-dependent virulence factors in Pseudomonas aeruginosa . One study [40] has noted that extracts of T. chebula were even more inhibitory to the gram-negative bacteria Klebsiella pneumoniae compared with Gram-positive S. aureus .…”
Section: Discussionmentioning
confidence: 99%
“…Combretaceae is a relatively small family with 10 genera and 530 species [15]. Extracts containing the flavonoids catechin and naringenin [37] from Combretum spp., ellagic acid derivatives from Terminalia chebula [38] and from Anogeissus leiocarpus [39] have been linked to inhibition of the QS-dependent virulence factors in Pseudomonas aeruginosa . One study [40] has noted that extracts of T. chebula were even more inhibitory to the gram-negative bacteria Klebsiella pneumoniae compared with Gram-positive S. aureus .…”
Section: Discussionmentioning
confidence: 99%
“…The microdilution method was used to determined MIC values on P. aeruginosa PAO1 and C. violaceum CV026 according to [13]. An appropriately diluted bacterial culture was added to each well containing test extracts in order to obtain a final concentration range of 5 mg/mL to 0.15625 mg/mL.…”
Section: Determination Of Minimum Inhibitory Concentration (Mic)mentioning
confidence: 99%
“…and Perr. (Combretaceae) traditionally used to treat respiratory diseases and wound, reduces the production of QS-controlled factors and gene expression [13]. These preliminary results lead to select some medicinal plants of Burkina faso flora for screening their anti-QS activity.…”
Section: Introductionmentioning
confidence: 99%
“…The production of a purple pigment, violacein, controlled by QS system in Chromobacterium violaceum making this strain an excellent biomonitor for the research of anti-QS compounds (Yong and Zhong, 2012). Thus, many plants have been widely screened for their anti-QS activity (Adonizio et al, 2008a;Ouedraogo and Kiendrebeogo, 2016;Vandeputte et al, 2010). Phenolic compounds isolated from Combretaceae exhibited anti-QS activity and reduced the production of QS-controlled virulence factors of P. aeruginosa (Adonizio et al, 2008b;Taganna et al, 2011;Vandeputte et al, 2010).…”
Section: Introductionmentioning
confidence: 99%