Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis

Kim, Min-Jong; Kim, Hana; Kang, Kyung-Sun; Baek, Nam‐In; Kim, Daekeun; Kim, Young-Seol; Kim, Sung Hoon; Jean, Byung-Hun

doi:10.1016/j.intimp.2004.07.001

Cited by 56 publications

(31 citation statements)

References 30 publications

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“…[14][15][16] To avoid the side effects, development of orally active small molecules that potentiate the expression and activity of NGF is warranted. 17,18) The extracts of plants from the Dioscorea genus were reported to exhibit hypoglycemic, 19) immunostimulatory, 20) and anti-inflammatory effects, 21) as well as anti-tumor 22) and anti-osteoporotic activity. 23) Dioscorea japonica THUNBERG.…”

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confidence: 99%

DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells

Won

Ahn

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et al. 2015

Biological & Pharmaceutical Bulletin

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confidence: 99%

DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells

Won

Ahn

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et al. 2015

Biological & Pharmaceutical Bulletin

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“…Various species of Dioscorea have been used as a traditional medicine for the treatment of diverse diseases including metabolic disorders such as obesity and diabetes, inflammatory diseases, pain and neuropathic diseases including diabetic neuropathy (8)(9)(10)(11)26). In particular, dioscin, a major steroidal saponin isolated from D. nipponica, and furostanol saponins from D. japonica have a neurotrophic effect by inducing NGF (12, 13).…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of DA-9801 (Dioscorea Extract) on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

Lee

Jin

Baek

et al. 2013

J Nutr Sci Vitaminol

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Summary It has been reported that DA-9801, an extract mixture of Dioscorea japonica Thunb and Dioscorea nipponica Makino, produces a neurotrophic activity. Therefore, this study was conducted to examine the neuroprotective effects of DA-9801 in streptozotocininduced diabetic rats. The experimental rats were divided into six groups: the control group, Group I (non-diabetic rats treated with DA-9801), Group II (diabetic, non-treated rats) and Groups III, IV, and V (diabetic rats treated with DA-9801 at doses of 10, 50 or 100 mg/ kg/d). Following a 16-wk course of oral treatment with DA-9801, functional parameters (von Frey filament test, hot plate test), biochemical parameters (nerve growth factor (NGF), tumor necrosis factor (TNF)-a, interleukin (IL)-6) were measured. An immunohistochemical staining was done to assess the neuroprotective effects of DA-9081 in the skin, sciatic nerve, gastric mucosa and renal cortex. In Week 8, pain was evoked by either tactile or thermal stimuli, whose threshold was significantly higher in Group III, IV and V than Group II. Western blot analysis showed a more significant increase in NGF and decrease in TNF-a and IL-6 in Group III, IV and V than in Group II (p,0.05). Moreover, following the treatment with DA-9801, a loss of intraepidermal nerve fibers (IENFs) was inhibited to a significant level in the skin, myelinated axonal fibers of the sciatic nerve and small nerve fibers innervating the gastric mucosa or renal cortex (p,0.05). Our results demonstrated that DA-9801 is a beneficial agent that protects the peripheral nerves in diabetic rats.

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“…마의 주요 활성으로 콜레스테롤 저하효과, 항당뇨, 혈당 강 화, 항산화, 항비만 등의 다양한 약리작용이 알려져 있다 [Kim 등 2004a;2004b;Kang 등, 2008a;2008b]. 마속식물의 대부 분은 당단백질, 점액성 다당류, 및 폴리페놀계 화합물을 함유하 고 있으며, 이들 성분에 의해 생리 활성을 보인다 [Han 등, 1990;Hironaka 등, 1990] Vasules are means±SD of 5 mice for each group.…”

Section: 고 찰unclassified

Lactic Acid Fermentation of Dioscorea batatas and Its Anti-Inflammatory Effects on TNBS-induced Colits Model

Hyun¹,

Hur²

2011

Journal of Applied Biological Chemistry

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To develop a health-aid preparation of Dioscorea batatas (DB), lactic acid fermentation was attempted using a mixed starter comprising of Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium longum. The anaerobic fermentation of a 10% DB flour suspension gave a uniform suspension of pH 3.65, containing 8×10 6 CFU/mL lactic acid bacteria. During the administration of the lactic acid fermented DB (FDB) and DB to trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model, histological lesions, morphological damage, and myeloperoxidase acitivity were significantly reduced at a dosage of 200 and 400 mg/kg/day. Dose-response (200 and 400 mg/kg/day) studies revealed that FDB pre-treatment of mice significantly ameliorated the appearance of diarrhoea and the disruption of colonic architecture. In FDB-pretreated mice, there was a significant reduction in the degree of both neutrophil infiltration (measured as decrease in myeloperoxidase activity) and weight loss rates. Theses findings suggest that FDB exerts beneficial effects in experimental colitis and may be useful in the treatment of inflammatory bowel disease.

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Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis

Cited by 56 publications

References 30 publications

DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells

DA-9801 Promotes Neurite Outgrowth <i>via</i> ERK1/2-CREB Pathway in PC12 Cells

The Protective Effects of DA-9801 (Dioscorea Extract) on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

Lactic Acid Fermentation of Dioscorea batatas and Its Anti-Inflammatory Effects on TNBS-induced Colits Model

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