Methanol Extract of &lt;i&gt;Hydroclathrus clathratus&lt;/i&gt; Inhibits Production of Nitric Oxide, Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; and Tumor Necrosis Factor-&amp;#945 in Lipopolysaccharidestimulated BV2 Microglial Cells via Inhibition of NF-&amp;#954B Activity

Jayasooriya, Rgpt; Moon, D-O; Chol, Y. M.; Yoon, C-H; Gy, Kim

doi:10.4314/tjpr.v10i6.4

Cited by 4 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10, (2021) different modes of action [5]. Hydroclathrus clathratus is a brown marine alga known to have anticancer, anti-herpetic, and anti-coagulant activities [6].…”

Section: Introductionmentioning

confidence: 99%

Chemical and biological characterization of lipid profile from Hydroclathrus clathraus

et al. 2021

View full text Add to dashboard Cite

This research addresses studying the lipid content of Hydroclathrus clathraus brown algae from the Red Sea, Egypt Region and their assess acute oral LD 50 of sterol fraction in albino mice and anticancer activity against different cancer cell lines including; colon cancer cell line (Caco-2) and liver cancer cell line (Huh-7) using MMT, apoptosis analysis, EGFR and genes' expression. Total lipids, glycolipid, sulfolipid, and phospholipid of Hydroclathrus clathraus content were 1mg/g, 0.08 mg/g, 0.25±0.01 mg/g and 0.57±0.04 mg/g respectively. The LD 50 of Hydroclathrus clathraus sterols was greater than 3g/kg in the mice. The major fatty acid is palmitic acid (67.04%). Polyunsaturated fatty acids content was arachidonic (8.05%), α-Linolenic acid (4.36%) and Linoleic acid (1.69%). The major sterols fractions were Hexacosane (18.54%), Octacosane (14.96%) and Nonadecane (13.31%). Cholesterol (8.32%), β-Sitosterol (2.08%) and Campesterol (1.36%) were presented as minor sterols. However, algal sterol showed the best potential antitumor activity with IC 50 of 0.22 µg/ml and 3.09µg/ml against CaCo2 and HuH7. These sterols fraction reduced tumor genesis by three mechanisms that firstly, the cells' apoptosis which may reduce the regulatory suppressive activity of the epidermal growth factor receptor (EGFR) enzyme, secondly, gene expression of bcl2 was downregulated and thirdly, it induced cell cycle arrest at the G1/S. Thus, algal sterols can be used as medicine to treat disorders liver and colon cancers

show abstract

“…10, (2021) different modes of action [5]. Hydroclathrus clathratus is a brown marine alga known to have anticancer, anti-herpetic, and anti-coagulant activities [6].…”

Section: Introductionmentioning

confidence: 99%

Chemical and biological characterization of lipid profile from Hydroclathrus clathraus

et al. 2021

View full text Add to dashboard Cite

show abstract

“…H.clathratus is known to possess anticancer, anti-herpetic, anti-inflammatory, and anticoagulant properties and is now used as a mineral supplement in cosmetics and as soil additive (fertilizer) for its high concentration of micronutrients [20]. Extracts of H.clathratus have antiviral [21], antitumour [22], and antimicrobial [23] activity. The present study was aimed to explore the natural antioxidant activity of H.clathratus against copper-induced lung injury in male white albino rats.…”

Section: Introductionmentioning

confidence: 99%

Hydroclathrus clathratus as anti-damaging agent against lung injury in male albino rats

Alharbi

2020

Beni-Suef Univ J Basic Appl Sci

View full text Add to dashboard Cite

Background: The present investigation is designed to evaluate the antioxidant and protective efficacy of the brown alga, Hydroclathrus clathratus (C.Agardh) M. Howe, against copper-induced lung injury in male albino rats. The present study was carried out on 24 adult male albino rats, they were randomly divided into four groups (n = 6) (A group, control rats; B group, rats received 100 mg/kg body weight of H. clathratus ethanolic extract; C group, rats augmented with 100 mg/kg body weight of CuSO 4 ; and D group, rats were supplemented with 100 mg/kg of CuSO 4 and 100 mg/ kg of H. clathratus ethanolic extract). All the experimental treatments were given orally and daily for 28 days. Results: It was showing that Cu treatment was found to induce lung toxicity, histopathologically, Cu revealed severe degenerative and necrotic lesions in the lung. Also, Cu caused a significant decrease in glutathione-S-transferase (GST) count and glutathione (GSH); meanwhile, malondialdehyde (MDA) content was increased. Consistently, mRNA and protein expression levels of proapoptotic (caspase-3 and Bax) marker showed a significant upregulation, whereas the anti-apoptotic (Bcl-2) level was significantly downregulated in lung tissues of CuSO 4-intubated groups. Moreover, H. clathratus plus CuSO 4-treated group showed improvement in the histopathological changes of lung injury. The bronchi and bronchioles appeared like those of the control, where the alveoli showed thin septa in some parts and thickened septa in other parts. Conclusion: Findings revealed that the natural antioxidant activity of H. clathratus could protect the lung tissue from the damage produced by CuSO 4 .

show abstract

Seaweed Flora of the European North Atlantic and Mediterranean

Pereira

2015

Hb25_Springer Handbook of Marine Biotechnology

View full text Add to dashboard Cite

Methanol Extract of <i>Hydroclathrus clathratus</i> Inhibits Production of Nitric Oxide, Prostaglandin E<sub>2</sub> and Tumor Necrosis Factor-&#945 in Lipopolysaccharidestimulated BV2 Microglial Cells via Inhibition of NF-&#954B Activity

Cited by 4 publications

References 31 publications

Chemical and biological characterization of lipid profile from Hydroclathrus clathraus

Chemical and biological characterization of lipid profile from Hydroclathrus clathraus

Hydroclathrus clathratus as anti-damaging agent against lung injury in male albino rats

Seaweed Flora of the European North Atlantic and Mediterranean

Contact Info

Product

Resources

About