Methanol-Induced Encephalopathy: a Case Report

Kim, Hyun Jin; Sunwoo, Moon Kyung; Lee, Jang Han; Choi, Yong Sun; Kim, Dae Yoon

doi:10.13104/imri.2017.21.1.61

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Of course, the mechanism responsible for necrosis is unknown. Nevertheless, the above outcomes make methanol metabolites (such as formic acid and metabolic acidosis) better indicators of methanol toxicity when measured 48 h after MeOH ingestion and remedial intervention [3,9,18].…”

Section: Discussionmentioning

confidence: 99%

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Cerebral Methanol Intoxication: A Case Report with Literature Review

Mesri¹,

Behzadnia²,

Nikpoor³

et al. 2022

cjm

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We report the case of a 24-year-old man admitted to the emergency room with a history of headache exacerbated. At the emergency room, he was unresponsive to drug or alcohol consumption. At this time, computed tomography (CT) did not detect the brain and abdomen lesions. At the intensive care unit (ICU), 6h later, he suddenly developed shallow respirations, followed by loss of consciousness, hypotension, and blurred vision. He was intubated immediately and underwent mechanical ventilation. Arterial blood gases and biochemical analyses indicated intense metabolic acidosis (Day1: pH 7.25, PCO2 49 mmHg, PO2 65 mmHg, HCO3 15 mmol/L and day 2, pH 7.32, PCO2 45 mmHg, PO2 60 mmHg, and HCO3=19 mmol/L) and elevated liver enzymes. The clinical diagnosis of toxic alcohol ingestion was based on the history, arterial blood gases results, and significant biochemical changes. In ICU, the patient underwent ethanol infusion and hemodialysis and the impression of methanol intoxication. He underwent redialysis with a minimal dose of heparin (5000 IU/mL). A second CT scan revealed basal ganglia ischemia, and an MRI scan exhibited clear abrasion and basal ganglia necrosis. Finally, he died due to severe methanol intoxication, but the probability of cerebral hemorrhage may be the cause of the patient death associated with heparin ©CIKD Publishing Received

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, the production of toxic metabolites by the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) can lead to bilateral necrosis of the central nervous system (CNS), which can be identified on computed tomography (CT) and magnetic resonance imaging (MRI) [8,9].…”

mentioning

confidence: 99%

Cerebral Methanol Intoxication: A Case Report with Literature Review

Mesri¹,

Behzadnia²,

Nikpoor³

et al. 2022

cjm

View full text Add to dashboard Cite

show abstract

Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy

Lim,

Lee

2024

J Korean Soc Radiol

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Spontaneous Bilateral Basal Ganglia Haemorrhage Secondary to Methanol Poisoning

Sohor,

Loh,

Pang

et al. 2023

Neurology India

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Methanol toxicity remains as major problem in the medical field.[1-3] With its active metabolite, formic acid often leads to severe metabolic acidosis and to some extend brain damaged.[4-6] We are reporting a case of brain hemorrhage at the right external capsule and left basal ganglia with mass effect and obstructive hydrocephalus in a methanol poisoning patient. A confused 29-year-old gentleman was brought into hospital. Initial investigation showed severe metabolic acidosis with raised anion gap. Initial brain CT scan was normal. Subsequently, serum methanol was reported to be high (112 mg/dL). Intravenous (IV) ethanol 10% was given without any delayed. As there was no improvement in his consciousness level, a repeat brain CT was performed and it showed multiple cerebral hemorrhage with obstructive hydrocephalus. Hence, clinicians should have high index of suspicion for cerebral hemorrhage in a patient with methanol toxicity, who presented with altered mental status and severe metabolic acidosis.

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Methanol-Induced Encephalopathy: a Case Report

Cited by 4 publications

References 5 publications

Cerebral Methanol Intoxication: A Case Report with Literature Review

Cerebral Methanol Intoxication: A Case Report with Literature Review

Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy

Spontaneous Bilateral Basal Ganglia Haemorrhage Secondary to Methanol Poisoning

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