Methanol leaf extract of Paullinia pinnata exerts sleep-enhancing and anticonvulsant effects via a mechanism involving the GABAergic pathway

Ajibade, Muideen  A.; Akhigbemen, Abigail M.; Okolie, Ngozi Paulinus; Ozolua, Raymond I.

doi:10.1016/j.eplepsyres.2022.106943

Cited by 6 publications

(2 citation statements)

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“…Ethyl acetate peel extract contains dodecanoic acid-1,2,3-propanetriyl ester (Figure 1). Dodecanoic acid, 1,2,3propanetriyl ester (1) is known as lauric acid ester (Ajibade et al 2022). It is found in the leaves, fruit peel and bark.…”

Section: Discussionmentioning

confidence: 99%

Chemical compositions, antioxidant and antibacterial activities of kepel (Stelechocarpus burahol) fruit flesh and peel extracts

SUNDARI,

HANDAYANI,

SURYANTI

2023

Biodiversitas

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Abstract. Sundari D, Handayani DS, Suryanti V. 2023. Chemical compositions, antioxidant and antibacterial activities of kepel (Stelechocarpus burahol) fruit flesh and peel extracts. Biodiversitas 24: 4668-4675. Kepel (Stelechocarpus burahol (Bl.) Hook f. & Th.) has been utilized by royalty in Java, Indonesia as perfume, deodorant and anti-agingagent. S. burahol fruit flesh has diuretic properties and can helpavoid kidney irritation. S. buraholpossesses anti-hyperuricemia and xanthine oxidase inhibitory properties, as well as antiseptic, anti-inflammatory, and antioxidant activity. Chemical contents and biological activities of S. burahol fruit and peel extracts were investigated in the present study. Based on GC-MS spectra, methanol fruits extract contains dodecanoic acid-1,2,3-propanetriyl ester. Methanol peel extract contains hexadecanoic acid methyl ester; 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene and dodecanoic acid-1,2,3-propanetriyl ester. Ethyl acetate peel extract contains dodecanoic acid-1,2,3-propanetriyl ester. LC-MS analysis revealed that ethyl acetate fruit flesh extract contains pelargonidin-malonylrhamnoside (anthocyanins), 8-epiiridodial glucoside tetraacetate (isoprenoid), epigallocatechin gallate (catechin) and 5-octadecenal (fatty aldehydes). Ethyl acetate fruit peel extract contains 1,5-dicaffeoylquinic acid (flavonoid), 1,6-di-o-galloylglucose (tannins), luteolin 7-O-glucoside (cynaroside),methyl hemiacetal in 3,4-DHPEA-EA (iridoids). Methanol extract of fruit flesh has strong antioxidant activity, whereas three other extracts have very strong antioxidant activities. S. burahol peel extract inhibited the S. aureus growth at a concentration extract of 15,000 to 25,000 ppm. These antioxidant and antibacterial activities are associated with the chemical composition of S. burahol fruit flesh and peel extracts. Further research into other biological functions and in vivo investigations are required for future studies.

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Section: Discussionmentioning

confidence: 99%

Chemical compositions, antioxidant and antibacterial activities of kepel (Stelechocarpus burahol) fruit flesh and peel extracts

SUNDARI,

HANDAYANI,

SURYANTI

2023

Biodiversitas

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“…When the material was returned to room temperature, the excitation and emission spectra were read from the spectrofluorimeter by heating it to 100 °C for 6 min. DA was measured at 330-375 nm, while NA was measured at 395-485 nm (Ajibade et al, 2022).…”

Section: Measurement Of Dopamine (Da) and Noradrenaline Levelsmentioning

confidence: 99%

Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

Jeyabalan

Bala

Kavimani³

et al. 2022

Front. Pharmacol.

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Obsessive-compulsive disorder (OCD) is a chronic and complex psychiatric disorder that usually includes both obsessions and compulsions. Morinda citrifolia L. (Noni) is a functional food and it is a well-known plant due to its potential therapeutic effects on human health in many disorders including neurological and neurodegenerative diseases. The purpose of this study was to evaluate the potential effect of M. citrifolia fruits extract (MCFE) against obsessive-compulsive disorder using the marble burying and nestlet shredding behavior mice models. In addition, brain neurotransmitters such as dopamine (DA), serotonin and noradrenaline (NA) were also assessed. Five mice were placed in each of the different groups, and the treatment was given to the animals for a period of 15 days. The marble burying test was evaluated for 30 min on days 1, 7, and 14 while the nestlet shredding test was evaluated for 60 min on days 2, 8, and 15. Treatments with MCFE (100 and 200 mg/kg, p.o.) significantly improved in both behavior tasks when compared to the control group. In addition, diazepam (2 mg/kg, i.p.) and fluoxetine (15 mg/kg,

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Combination and formulation of Ghanaian herbal products for the treatment and management of disease as potent health tonic

Archer,

Ayertey,

Mintah

et al. 2024

Herbal Formulations, Phytochemistry and Pharmacognosy

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Methanol leaf extract of Paullinia pinnata exerts sleep-enhancing and anticonvulsant effects via a mechanism involving the GABAergic pathway

Cited by 6 publications

References 57 publications

Chemical compositions, antioxidant and antibacterial activities of kepel (Stelechocarpus burahol) fruit flesh and peel extracts

Chemical compositions, antioxidant and antibacterial activities of kepel (Stelechocarpus burahol) fruit flesh and peel extracts

Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

Combination and formulation of Ghanaian herbal products for the treatment and management of disease as potent health tonic

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