Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl4 Induced Liver Toxicity in Rat

Oshaghi, Ebrahim Abbasi; Khodadadi, Iraj; Mirzaei, Fatemeh; Khazaei, Mozafar; Tavilani, Heidar; Goodarzi, Mohammad Taghi

doi:10.1155/2017/6081374

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…Total oxidant status (TOS) was measured using xylenol orange, and total antioxidant capacity (TAC) was measured using the ferric ion reducing antioxidant potential (FRAP) method. 22,30 The amount of MDA, a lipid peroxidation marker, was measured…”

Section: Antioxidant Markersmentioning

confidence: 99%

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NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study

Abbasi-Oshaghi¹,

Mirzaei²,

Pourjafar³

2019

IJN

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Purpose This study evaluated the effects of titanium dioxide nanoparticles (TiO 2 NPs) on liver and intestine of normal rats. Methods Male rats were divided into four groups as follows: 1) control rats, 2) control rats that orally received 10 mg/kg TiO 2 NPs, 3) control rats that orally received 50 mg/kg TiO 2 NPs, and 4) control rats that orally received 100 mg/kg TiO 2 NPs. After 30 days, the NLRP3 inflammasome pathway (NLRP3, caspase-1, and IL-1β), antioxidant pathway (superoxide dismutase [SOD], glutathione peroxidase [GPx], and catalase [CAT]), inflammatory pathway (inducible nitric oxide synthase [iNOS] and tumor necrosis factor-α [TNF-α]), and the apoptosis pathway (p53, Bax, Bcl-2, and caspase-3) were determined in the intestine and liver of the rats. H&E and Masson’s trichrome (MT) staining as well as TUNEL assay were used to examine the liver and the intestine. Biochemical factors, cytotoxicity, ROS generation, and apoptosis rate were also determined in HepG2 and Caco-2 cells. Results TiO 2 NPs in a dose-dependent manner increased cytotoxicity, oxidative stress, and apoptosis rate in Caco-2 and HepG2 cells. The administration of TiO 2 NPs significantly reduced antioxidant enzyme activity and gene expressions (SOD, CAT, and GPx) as well as glutathione (GSH) levels and total antioxidant capacity (TAC) in a dose-dependent manner. TiO 2 NPs also induced the apoptosis pathway and inflammatory pathway gene expressions and caspase-3 activity in the intestine and liver. TUNEL assay was in agreement with gene expressions. TiO 2 NPs also led to morphological changes in the liver and intestine. Conclusion TiO 2 NPs could have cytotoxic effects on the intestine and liver structure and function by inducing oxidative stress, inflammation, and apoptosis.

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Section: Antioxidant Markersmentioning

confidence: 99%

“…Journal of Nanomedicine downloaded from https://www.dovepress.com/ by 44.224.250.200 on 06-Jul-2020 For personal use only. International Journal of Nanomedicine 2019:14 submit your manuscript | www.dovepress.com Dovepress Dovepress 1922 abbasi-Oshaghi et al colorimetrically using thiobarbituric acid reactive substances (TBARS) 22,30. …”

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confidence: 99%

NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study

Abbasi-Oshaghi¹,

Mirzaei²,

Pourjafar³

2019

IJN

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“…The MDA concentration, as a marker of lipid peroxidation, was measured by a spectrofluorometric method based on the reaction of thiobarbituric acid with MDA. Finally, data were expressed as nmol/mg protein (21,22).…”

Section: Determination Of Malondialdehyde Levelsmentioning

confidence: 99%

Effects of Resistance, Endurance, and Concurrent Exercise on Oxidative Stress Markers and the Histological Changes of Intestine After Morphine Withdrawal in Rats

Salehi

Zarrinkalam

Mirzaei

et al. 2018

Avicenna J Med Biochem

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Objectives: The aim of this study was to evaluate the effects of resistance, endurance, and concurrent exercise on oxidative stress markers and histological changes of the intestine after morphine withdrawal in rats. Methods: A total of 30 male Wistar rats were randomly divided into 5 groups (n=6) including healthy control, withdrawal (rat received morphine for 21 days and 8 weeks of withdrawal period), withdrawal + endurance exercises, withdrawal + resistance exercises, and withdrawal + concurrent exercises. The rats practiced endurance, resistance, and concurrent exercises for 10 weeks. Then, their intestines were removed and used for biochemical and histological analysis. Next, several factors were measured such as total protein levels, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC), and total oxidant status (TOS). Finally, the morphological alteration of intestine was examined under the light microscope. Results: Morphine withdrawal significantly increased the levels of MDA in the intestine of withdrawal rats compared to those of the control group while endurance, resistance, and concurrent exercise reduced the MDA levels in the intestine. In addition, morphine withdrawal led to a decrease in TAC and GSH levels in the intestine compared to control rats whereas endurance, resistance, and concurrent exercise noticeably increased TAC and GSH levels. Interestingly, the change in the concurrent group was more significant. Moreover, the levels of TOS demonstrated a significant increase in the addicted rat as compared to the control group. Conversely, endurance, resistance, and concurrent exercise significantly decreased TOS levels and the reduction was more significant in the concurrent group. Finally, the intestine of withdrawal rat was morphologically abnormal while it restored by the exercise. Conclusion: Overall, endurance, resistance, and concurrent exercise significantly normalized oxidative stress and the morphological changes of the intestine in withdrawal rats.

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“…19 The antioxidant properties of the above phytoconstituents are because of their redox activities, which allow them to have different activity such as hydrogen donors, reducing metabolites, reactive oxygen species quenchers and metal chelation. 20 It was reported that water extract fraction of dill had significant DPPH scavenging activity. The stable free radical of DPPH value is generally used to evaluate plant antioxidant ability by working as hydrogen donors or free radical scavengers.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Anethum Graveolens in a Murine Model of Gentamicin Induced Nephrotoxicity

Srivastava¹,

Rashmi

Shenoy

et al. 2018

JYP

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Background: Antioxidant rich herbs possess significant activity against various disease conditions induced by oxidative stress. Anethum graveolens is a rich source of bioactive compounds that possess varying pharmacological activities including antioxidant. Objective: To evaluate the nephroprotective effect of aqueous extract of Anethum graveolens seeds in a murine model of gentamicin induced renal damage. Materials and Methods: Wistar albino rats of either sex, weighing 150-200g were divided into 5 groups; normal saline, gentamicin (80 mg/kg, i.p), aqueous extract of Anethum graveolens seeds at 0.5, 1 and 2g/kg/ body wt., p.o, for 8 days, the extract being administered 3 days prior and concurrently with gentamicin for 5 days. Serum urea, creatinine, uric acid, blood urea nitrogen (BUN) analyses and histopathological examination of kidney were performed. Results: Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in Serum urea, creatinine, uric acid and BUN (107.5±16.92 mg/dl, 0.88±0.09 mg/dl,3.05±0.29 mg/dl and 47.80±9.07 mg/dl respectively) as compared to saline treated animals. Co-administration of aqueous extract of Anethum graveolens at doses 0.5, 1 and 2g/kg/ body wt decreased the rise in these parameters in a dose dependent manner. However statistical significance was obtained only with 1 and 2g/kg body wt doses employed, when compared to the gentamicin treated group. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas the test extract mitigated the severity of gentamicin induced renal damage. Conclusion: Our data suggests that aqueous extract of Anethum graveolens seeds exhibits renoprotective effect in gentamicin induced renal damage probably due to its antioxidant actions. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl₄ Induced Liver Toxicity in Rat

Cited by 15 publications

References 27 publications

<p>NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study</p>

<p>NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study</p>

Effects of Resistance, Endurance, and Concurrent Exercise on Oxidative Stress Markers and the Histological Changes of Intestine After Morphine Withdrawal in Rats

Nephroprotective Effect of Anethum Graveolens in a Murine Model of Gentamicin Induced Nephrotoxicity

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