Methanolic Extract of Muntingia Calabura L. Mitigates 1,2-Dimethyl Hydrazine Induced Colon Carcinogenesis in Wistar Rats

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine-Induced Colorectal Carcinogenesis in the Rat

“…Therefore, these enzymes prevent oxidative damage [49]. In the present study, SOD and CAT activities were decreased in DMH-induced CRC, as observed in previous studies, although the results were not statistically significant [9,34,38]. These results were expected since oxidative stress was reported to increase as CRC carcinogenesis occurs [49].…”

“…A study performed by Jia and Han [37] presented a 100% incidence of tumors at the end of 32 weeks, using a lower dose when compared to our study (20 mg/kg vs. 40 mg/kg). However, like our investigation, other studies with lower carcinogen doses and short duration only reported preneoplastic lesions [34,38]. The comparative analysis of these studies suggests that our protocol can be improved by reducing the dose of carcinogen administered, opting for subcutaneous injections to facilitate the weekly procedure, choosing younger animals, and having a longer protocol.…”

“…However, the analysis of serum CRP, albumin, and IL-6, inflammatory markers linked to CRC progression and survival [ 32 ], did not support systemic inflammation at these stages of the disease. Previous findings showed higher CRP and IL-6 serum levels in DHM-induced groups than controls but in more advanced stages of the disease [ 33 , 34 ]. In fact, although there was no evidence of systemic inflammation, an increase in local inflammation (evaluated according to Tian et al [ 17 ] was noted in the cecum, small intestine, and colon of animals belonging to the groups induced by DMH when compared to the respective controls.…”

Evaluation of the combined effects of Turkish mad honey and 5-Fluorouracil in colon cancer model in rats

“…On the other hand, Dogan et al (13) reported that there were no significant differences between the groups in terms of serum TOS and OSI levels in IR model rats. Jisha et al (26) reported a positive correlation between the severity of oxidative stress and inflammation and the developmental rate and severity of the pathogenesis of the tumor in the colon cancer model. In addition, they found significant differences in the serum CRP levels between the studied groups.…”

Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine

“…[159][160][161][162][163][164][165][166][167][168][169][170][171] Metabolomic analysis shows that of the 43 metabolites identified, 32 were compounds with biological activities. 166 This plant material has been reported to be a candidate material for anticancer, [172][173][174][175][176] antihypertensive, 177,178 antinociceptive, 167,[179][180][181][182] cardioprotector, 183 antibacterial, 166 antioxidants, 167,[169][170][171][184][185][186][187] anti-gastric ulcer and gastroprotector, [188][189][190][191][192] hepatoprotector, 185,159,160,193,194 antispasmodic 195 , and antihyperuricemic. 196 The potency of M. calabura as an anti-inflammatory can be caused by inhibiting lipoxygenase (LOX) activity, 184 inhibiting paw swelling carrageenan-induced paw of an animal model, 186 suppressing COX-2 expression, inhibit the formation of p...…”