Methanolic extract of Moringa oleifera leaves mediates anticancer activities through inhibiting NF- and #120581;B and enhancing ROS in Ehrlich ascites carcinoma cells in mice

Das, Priyanath; Asha, Saharia Yeasmin; Siddika, Mst. Ayesha; Siddika, Ayesha; Tareq, Abu Montakim; Islam, Farhadul; Khanam, Jahan Ara; Rakib,

doi:10.5455/jabet.2021.d116

Cited by 9 publications

(2 citation statements)

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“…The antiproliferative effect of methanolic extract of Moringa oleifera leaves (MOLME) was studied in Swiss albino mice using Ehrlich ascites carcinoma cell lines. Canthaxanthin, as an important bioactive component of MOLME, has been found to inhibit cancer initiation, showing a 65% decrease in mammary cancer incidence in rats induced by dimethylbenzanthracene (Das et al, 2021 ). Oral administration of canthaxanthin has led to a significant reduction in tumor size and number in hamster buccal pouch carcinogenesis (Schwartz et al, 1988 ).…”

Section: Genetically Modified Organisms As Canthaxanthin Sourcesmentioning

confidence: 99%

Microbial canthaxanthin: an orange-red keto carotenoid with potential pharmaceutical applications

Gaur,

Bera

2023

bta

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Canthaxanthin is an orange-red keto-carotenoid that occurs naturally and is also manufactured by synthetic methods for regular applications. In nature, canthaxanthin mainly exists in microbes such as different bacterial species, fungi, and algae, as well as in animals such as crustaceans, certain fishes, and birds. However, the amount of canthaxanthin produced in these organisms varies significantly. Additionally, the compound can be generated from genetically modified organisms using genetic engineering techniques Canthaxanthin finds extensive application as an additive in animal feed, in the pharmaceutical industry, as a coloring agent for various food products, and in cosmetics. It has powerful antioxidant properties and plays a role in lipid metabolism, neuroprotection, and immunomodulation. This article gives an extensive insight into the structure and methods of synthesis of canthaxanthin along with its various newly discovered sources identified so far. The significant applications of canthaxanthin, particularly its role in pharmaceuticals, are critically evaluated. Furthermore, the article discusses future aspects and challenges associated with canthaxanthin production and regulation.

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Section: Genetically Modified Organisms As Canthaxanthin Sourcesmentioning

confidence: 99%

Microbial canthaxanthin: an orange-red keto carotenoid with potential pharmaceutical applications

Gaur,

Bera

2023

bta

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“…This plant's various parts have medicinal applications, such as antifungal, antiviral, anti-inflammatory, etc. [5][6][7][8]. Moringa leaves also have a low calorific value and can be included in the diet of obese individuals [9].…”

Section: Introductionmentioning

confidence: 99%

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Akter¹,

Rahman²,

Moni³

et al. 2021

Plants

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Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as well as (ii) the effectiveness of M. oleifera in the anti-inflammation and antioxidant processes of the kidney while minimizing all potential side effects. In addition, we proposed a hypothesis to improve M. oleifera based drug development. This study was updated by searching the key words M. oleifera on kidney diseases and M. oleifera on oxidative stress, inflammation, and fibrosis in online research databases such as PubMed and Google Scholar. The following validation checking and scrutiny analysis of the recently published articles were used to explore this study. The recent existing research has found that M. oleifera has a plethora of health benefits. Individual medicinal properties of M. oleifera leaf extract, seed powder, stem extract, and the whole extract (ethanol/methanol) can up-increase the activity of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while decreasing the activity of inflammatory cytokines such as TNF-α, IL-1β, IL-6, and COX-2. In our study, we have investigated the properties of this plant against kidney diseases based on existing knowledge with an updated review of literature. Considering the effectiveness of M. oleifera, this study would be useful for further research into the pharmacological potential and therapeutic insights of M. oleifera, as well as prospects of Moringa-based effective medicine development for human benefits.

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Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

Das

Ghosh

2022

Chirality

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Chiral compounds find importance as drugs and therapeutic targets. Enantiomers of chiral drugs have been found to show different biological properties like pharmacokinetics, toxicology, pharmacology, metabolism, and so forth. In this study, we have identified the chiral compounds present in the medicinal plant Adhatoda vasica Nees (Justicia adhatoda Linn). Phytochemical investigation on the leaves of Justicia adhatoda resulted in the identification of 27 chiral compounds. We report diverse compounds identified in the crude methanolic extract of Justicia adhatoda leaves by GC-MS analysis exhibiting diverse biological activities. Quantitative analysis of anticancer compound dihydroxycolchicine from the methanolic extract of J. adhatoda leaves was done by external standard method, and the amount of anticancer compound dihydroxycolchicine was found to be 87.823 mg/l indicative of moderate production in the leaves. Therefore, the extract of leaves of Justicia adhatoda can be used as a potential source of chiral bioactive molecules of pharmacological importance for drug synthesis.

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Methanolic extract of Moringa oleifera leaves mediates anticancer activities through inhibiting NF- and #120581;B and enhancing ROS in Ehrlich ascites carcinoma cells in mice

Cited by 9 publications

References 0 publications

Microbial canthaxanthin: an orange-red keto carotenoid with potential pharmaceutical applications

Microbial canthaxanthin: an orange-red keto carotenoid with potential pharmaceutical applications

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Determination of chiral bioactive molecules in Justicia adhatoda leaves by GC–MS

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