Methanolic Extract of Peel of Citrus maxima Fruits Exhibit Analgesic, CNS Depressant and Anti-inflammatory Activities in Swiss Albino Mice

Ibrahim, Md.; Amin, Mohammad Nurul; Millat, Md. Shalahuddin; Raju, Jahangir Alam; Hussain, Md. Saddam; Sultana, Farhana; Islam, Md. Monirul; Hasan, Md. Murad

doi:10.5530/bems.4.1.3

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…So, we applied two methods, including open field test and whole board test for CNS depressant potential experiment where those mice that received a dose of 400 mg/kg body weight showed the highest result (54.40 ± 4.51) compared to the positive control (14.2 ± 3.70) depicting the amplitude of movements compared to the standard drug diazepam. Because the locomotor activity measures the CNS excitability, a decrease in it may indicate the extract's depressing or sedative properties (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Roy

Bhowmik

Uddin

et al. 2022

J Herbmed Pharmacol

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Introduction: Lablab purpureus, under the family of Fabaceae, is a plant with various pharmacological activities. The present study was aimed to investigate the phytoconstituents, membrane stabilizing activity, central nervous system (CNS) depressant potential, and gastrointestinal (GI) motility of the methanol extract of L. purpureus seeds (MELPS).Methods: The methanol plant extract was screened for different phytochemical groups. Mice were classified into four groups for in vivo activities. Group-I was designated as negative control and received distilled water (10 mL/kg body weight); group-II served as positive control and received diazepam (1 mg/kg body weight). Group-III and group-IV both were experimental groups and received plant extract at 200 and 400 mg/kg body weight, respectively.Results: Alkaloids, carbohydrates, saponins, glycosides, tannins, phenols, flavonoids, and proteins were found after phytochemical analysis. On hypotonic solution-induced hemolysis of erythrocyte membrane, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (60.51 ± 0.889), and on heat-induced hemolysis, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (33.97 ± 0.21). In the case of the CNS depressant potential experiment, mice that received a sample at a dose of 400 mg/kg body weight showed the highest result (54.40 ± 4.51) compared with the positive control (14.2 ± 3.70) (P < 0.001). Similarly, 400 mg/kg dose sample exhibited the highest percentage of inhibition (60.51 ± 0.889) of hemolysis and GI motility (22.26%).Conclusion: It can be concluded that the MELPS has potential membrane stability, CNS depressant, and antimotility effects.

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Section: Discussionmentioning

confidence: 99%

Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Roy

Bhowmik

Uddin

et al. 2022

J Herbmed Pharmacol

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“…In general, the peel waste of Citrus contributes to anti-oxidant, anti-microbial, cardio-protective, anti-inflammatory, anti-diabetic, anti-cancer, and many more health-beneficial properties. It has been found that the biological activity is due to the presence of phytochemicals such as flavonoids, phenolics, vitamins, terpenes, etc., in Citrus waste [96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112]. Some of the important bioactivities of Citrus co-product (peel) are shown in Table 5.…”

Section: Citrus-bioprospecting and Valorizationmentioning

confidence: 99%

Sustainable Approaches for Biodiversity and Bioprospecting of Citrus

Kumari¹,

Bhowal²,

Suprasanna

2023

Sustainability

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Citrus, belonging to the Rutaceae family, is a commercial fruit worldwide, and it is mainly recognized for its nutritional, anti-oxidant, and significant medicinal properties. Citruses are a group of multifaceted fruit crops with a rich traditional knowledge, deeply rooted in ethnic culture, and the fruits have been considered to be health-protecting and health-promoting food supplements since ancient times. The presence of secondary metabolites and their bioactivities has led to the development of new alternative drugs in recent years. Diverse secondary metabolites such as flavonoids, alkaloids, carotenoids, phenolic acids, and essential oils and their high bioactive properties have imparted great value to human health based on their anti-oxidative, anti-inflammatory, anti-cancer, cardiovascular protective, and neuroprotective effects. The indigenous Citrus species of India—mainly Northeast India—have distinctive and valuable genetic traits, such as resistance to biotic and abiotic stress, distinctive aroma, flavor, etc. Hence, these species are considered to be repertoires of valuable genes for molecular breeding aimed at quality improvement. There is a need for awareness and understanding among the citrus-producing countries of the exploitation of biodiversity and the conservation of Citrus for sustainable development and bioprospecting. The current review presents a holistic view of Citrus biodiversity from a global perspective, including phytochemical constituents and health benefits. Advanced biotechnological and genomic approaches for Citrus trait improvement have also been discussed to highlight their relevance in Citrus improvement.

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“…The analgesic property of the methanolic extract of its peel was examined by formalin-induced licking and biting model and acetic acid-induced writhing model. The extract at a higher dose (500 mg/kg) showed satisfactory analgesic activity (73.34%) in the acetic acid-induced pain model as compared to 87.13% activity shown by standard drug diclofenac sodium at 10 mg/kg dose [ 118 ]. In another experiment, the analgesic activity of leaf, stem, and fruit was compared by using the tail-flick method in rats, acetic acid-induced writhing, and the hot plate method in mice.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Many studies suggested that the mechanism responsible for analgesic and anti-inflammatory activity is due to inhibition of prostaglandin synthesis. Also the presence of flavonoids and their respective aglycones like hesperetin and naringenin might be the reason for the potent anti-inflammatory and analgesic activity [ 10 , 118 – 120 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive Chemical Constituents and Pharmacological Activities

Sapkota¹,

Devkota

Poudel

2022

Evidence-Based Complementary and Alternative Medicine

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Citrus maxima (Burm). Merr. (family Rutaceae), commonly known as Pomelo, is an ethnomedicinally, pharmacologically, and phytochemically valued species. Various ethnomedicinal reports have revealed the use of C. maxima for cough, fever, asthma, diarrhea, ulcer, and diabetes and as a sedative. Numerous phytochemicals have been reported from C. maxima such as polyphenols, terpenoids, sterols, carotenoids, vitamins, and amino acids. The plant possesses significant bioactivities like antioxidant, antimicrobial, anti-inflammatory, analgesic, anticancer, antidiabetic, anti-Alzheimer’s disease, insecticidal, anxiolytic, hepatoprotective, antimalarial, and antiobesity. Extensive research is necessary to explore the detailed mechanism of action of extracts and compounds to design effective medicines, herbal products, and functional foods.

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Methanolic Extract of Peel of Citrus maxima Fruits Exhibit Analgesic, CNS Depressant and Anti-inflammatory Activities in Swiss Albino Mice

Cited by 7 publications

References 11 publications

Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Sustainable Approaches for Biodiversity and Bioprospecting of Citrus

Citrus maxima (Brum.) Merr. (Rutaceae): Bioactive Chemical Constituents and Pharmacological Activities

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