Methicillin Resistance and Staphylococcus aureus in Nasal Cultures Before and During the Covid-19 Pandemic: A Comparison of the Results

Altıntaş, Mustafa; Kar, Murat; Tigli, Gul Aydin; Çekın, Yeşim

doi:10.5152/ejra.2022.22056

Cited by 3 publications

(4 citation statements)

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“…Although effects of prior COVID diagnosis on respiratory complications have been seen in prior literature, there are no studies correlating PCR COVID diagnosis to either increased MRSA nares colonization or supplemental oxygen requirements in arthroplasty patients. MRSA nares colonization is a known risk factor for periprosthetic joint infections, and prior reports indicate increased MRSA colonization during the COVID pandemic [16]. Our study indicates prior PCR COVID diagnosis had no increased risk for MRSA colonization despite theories on the decreased nasal immune response to respiratory co-pathogens after COVID infection [17].…”

Section: Discussionmentioning

confidence: 45%

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty

Lung¹,

Taka²,

Donnelly³

et al. 2022

Cureus

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IntroductionAlthough a substantial portion of the United States population has been infected with and recovered from Coronavirus , many patients may have persistent symptoms and complications from disease-driven respiratory disease, arrhythmias, and venous thromboembolism (VTE). With institutions resuming elective total joint arthroplasties (TJA), it is unclear whether a prior resolved diagnosis of COVID has any implications on postoperative outcomes. MethodsAll elective TJA performed in 2021 at our institution were retrospectively reviewed and a history of prior COVID+ result recorded. Baseline demographics, days from prior COVID+ result to surgery date, preoperative methicillin-resistant Staphylococcus aureus (MRSA) nares colonization, and laboratory markers were obtained to determine baseline characteristics. Postoperative estimated blood loss (EBL), length of stay (LOS), rate of revision surgery, and discharge destination were compared between groups. Perioperative and postoperative rates of VTE, urinary tract infection (UTI), pneumonia, postoperative oxygen supplementation, cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery were recorded. ResultsOf the 155 elective TJA performed in 2021, 24 patients had a prior COVID+ diagnosis with a mean of 253 days from positive result to surgery date. There were no significant differences in baseline demographics, comorbidities, and preoperative lab markers between groups. Surgeries on patients with a prior COVID+ had a significantly higher EBL (260 vs 175cc), but postoperative outcomes of VTE, UTI, pneumonia, oxygen supplementation requirement, nares MRSA+, cardiac disease, and infection rates between groups were similar. Bivariate logistic regression revealed increased days from COVID+ diagnosis (>6 months) to surgery date were associated with a shorter LOS. ConclusionAlthough a prior COVID+ diagnosis had increased intraoperative blood loss, there were no significant differences in respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA. This study suggests that asymptomatic C+ patients receiving elective TJA do not require more aggressive prophylactic anticoagulation or antibiotic regimens to prevent VTE or perioperative infections. As institutions around the nation resume pre-COVID rates of arthroplasty surgeries, a prior diagnosis of COVID appears to have no effects on postoperative complications.

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Section: Discussionmentioning

confidence: 45%

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty

Lung¹,

Taka²,

Donnelly³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Strikingly, the incidence of MRSA infections increased by 13% from 2019 to 2020 in the USA . Similarly, significant increases in MRSA infections were reported in Turkey during 2020 as compared to 2019 from nasal swabs of around 2700 participating patients . Compiled data from various reports around the world suggest that MRSA was one of the most frequent pulmonary infection causative agents in patients with COVID-19 .…”

Section: Resultsmentioning

confidence: 96%

“…12 Similarly, significant increases in MRSA infections were reported in Turkey during 2020 as compared to 2019 from nasal swabs of around 2700 participating patients. 72 Compiled data from various reports around the world suggest that MRSA was one of the most frequent pulmonary infection causative agents in patients with COVID-19. 73 More localized prescription rates and measurement of the antibiotic residues in the wastewater could help substantiate any relationships and other drivers for these observations such as ARG-host selection and co-and cross-selection.…”

Section: Metagenomic Insights Into Arg Abundancementioning

confidence: 99%

Changes in Prevalence but Not Hosts of Antibiotic Resistance Genes during the COVID-19 Pandemic versus Prepandemic in Wastewater Influent

Deshpande,

Ehasz,

Eramo

et al. 2023

ACS EST Water

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The COVID-19 pandemic offered a unique opportunity to study shifts in environmental antibiotic resistance that could be associated with the changes in disinfectant and/or antibiotic usage patterns, coinfections, or other behaviors. The aim of this study was to document temporal changes (pre-, early-, versus later-pandemic) in antibiotic resistance genes (ARGs), ARG hosts, biomarkers of potential coinfections, and the total microbiome in municipal wastewater influent from one separate sanitary and one combined sewer system. The 16S rRNA gene copy normalized concentration of qacE was higher in early- than prepandemic samples, and sul1 and tet(G) were higher in early- than later-pandemic samples. Metagenomics revealed significant changes in the abundance of the macrolide and sulfonamide ARG classes. COVID-19 cases positively correlated with the disinfectants/antiseptics group of ARGs and negatively correlated with the sulfonamide and aminoglycoside resistance classes. Discussion is provided regarding the correspondence of these observations with antibiotic prescription pattern changes during the study period. Putative waterborne pathogens were identified, which is of potential interest for understanding the prevalence of community coinfections. No changes in host-ARG associations were observed. Overall, the results of this study may help in understanding the impact of the pandemic and/or lack thereof on another public health crisis: antibiotic resistance.

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“…A tendência temporal da incidência de infecção por Staphylococcus spp. resistentes a antibióticos antes e durante a pandemia da COVID-19 também apresenta heterogeneidade, sendo crescentes em alguns estudos (Polly et al, 2022;López-Jácome et al, 2022) e declinante em outros (Dias et al, 2021;Karatas et al, 2021;Altintas et al, 2022, Jeon et al, 2022. Essas disparidades podem ser reflexo da continuidade de padrões anteriores ou ainda modificadas pelas condições próprias da pandemia, com maior ou menor cuidado no controle de infecções hospitalares e protocolos de antibioticoterapia.…”

Section: Cusumano Et Al (2020) Examinaram 2679 Pacientes Internados C...unclassified

Infecções por Staphylococcus spp. concorrentes à COVID-19: uma revisão de literatura

Norberg¹,

Norberg²,

Manhães

et al. 2022

RSD

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Espécies do gênero Staphylococcus estão entre os principais agentes causadores de infecções de origem nosocomial, e é especialmente preocupante o aumento de cepas multidrogarresistentes que circulam no ambiente hospitalar, colonizando e infectando pacientes e profissionais de saúde. Infecções secundárias são um agravo importante na COVID-19. O objetivo desse trabalho é analisar através da literatura científica atual o impacto da infecção concomitante por espécies do gênero Staphylococcus em pacientes com COVID-19. A análise da literatura científica atual permite inferir que há uma grande heterogeneidade quanto à incidência dessa coinfecção/superinfecção/colonização. Também foi verificada heterogeneidade em relação aos níveis de resistência a antibióticos das cepas isoladas e tendências divergentes quanto à incidência temporal desse patógeno bacteriano nas infecções secundárias à COVID-19. Essas diferenças provavelmente refletem padrões locais, como os perfis de resistência e infecções secundárias anteriores à pandemia, assim como os níveis de controle de infecções hospitalares de cada unidade de saúde. Fatores como o tempo de internação, o uso de ventilação mecânica e a aquisição de cepas de Staphylococcus spp. de origem hospitalar influenciam diretamente nas taxas de infecção secundária e o prognóstico em pacientes com a COVID-19. Mesmo considerando a heterogeneidade dos resultados, as taxas de mortalidade podem ser consideradas altas em pacientes que apresentam infecção concorrente por Staphylococcus spp. na forma grave da virose causada pelo SARS-CoV-2, com taxas que podem ser superiores a 90%.

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Methicillin Resistance and Staphylococcus aureus in Nasal Cultures Before and During the Covid-19 Pandemic: A Comparison of the Results

Cited by 3 publications

References 0 publications

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty

Changes in Prevalence but Not Hosts of Antibiotic Resistance Genes during the COVID-19 Pandemic versus Prepandemic in Wastewater Influent

Infecções por Staphylococcus spp. concorrentes à COVID-19: uma revisão de literatura

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