Methicillin resistantStaphylococcus aureusmeningitis

Pereira, Noella Maria Delia; Shah, Ira; Ohri, Alpana; Shah, Forum

doi:10.1093/omcr/omv064

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Cephalosporin was anticipated. [18][19][20] In about 9 patients Aminoglycoside was combinedly used with anti-MRSA and β-Lactam. In 4 patients anti-MRSA agents were added later on when Gram-positive cocci were found.…”

Section: Discussionmentioning

confidence: 99%

An observational study for evaluation of antibiotic utilization and growing resistance against antibiotics in pediatric patients suffering from meningitis in a tertiary care hospital

Bhattacharyya

Ghosh

2023

Asian J Med Sci

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Background: Meningitis, inflammation of the meninges with systemic septicemia, from the bacterial, viral, or fungal origin, is a fatal disease in all age groups, particularly infants and children. The present study was done to evaluate the usage of antibiotics in pediatric patients with meningitis in a tertiary care hospital. Aims and Objectives: The study was conducted to evaluate the prescription pattern of antibiotics for pediatric patients suffering from meningitis. The efficacy of antibiotics, combination of antibiotics, and the resistance developed against them were reevaluated. Materials and Methods: An observational, noninterventional study with 34 pediatric patients (The mean age of the patients were 6.17 year. ±4.84 SD) admitted in Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar from September 2012 to February 2014 were evaluated. Data were collected after the approval of the research protocol by the Institutional Ethics committee, KIMS from case sheets of patients from the ward as well as the Medical Record and Data section. Comparative statistical analysis was done by using student’s t-test in respect of data measured on a continuous scale. All differences with P<0.05 were labeled as statistically significant. Results: Ceftriaxone±ß lactamase inhibitor (βLI) (77.4%), and Cefoperazone±βLI (12.9%) were the most frequently used cephalosporin. In 55.8% of patients, three or more antibiotics in combination were given. Two drugs regimen like β lacatam+aminoglycoside in 23.5% of patients and β lactam+anti-Methicillin-resistant Staphylococcus aureus (MRSA) in 20.6% were given. Emerging resistance pattern against both Gram-positive cocci and Gram-negative bacilli to penicillins, cephalosporins, and aminoglycosides which are the primary first-line drugs has been observed. Conclusion: Very severe meningitis patients were treated with multiple antibiotics including anti-MRSA agents. High resistance (≥60%) was observed against β lactams.

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Section: Discussionmentioning

confidence: 99%

An observational study for evaluation of antibiotic utilization and growing resistance against antibiotics in pediatric patients suffering from meningitis in a tertiary care hospital

Bhattacharyya

Ghosh

2023

Asian J Med Sci

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“…6 Indeed, CA-MRSA may occur without any underlying diseases and usually presents with soft tissue and skin infection. 8 Spontaneous meningitis caused by CA-MRSA is rare and usually present in older patients with immunodeficiency or diabetes mellitus. 7 In China, reports on CA-MRSA meningitis patients are very scarce.…”

Section: Discussionmentioning

confidence: 99%

Community-Acquired Methicillin-Resistant Staphylococcus aureus ST59 in a Chinese Adult with Meningitis: A Case Report from China

Chen¹,

Chen²,

Zhao³

et al. 2020

IDR

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed by cerebrospinal fluid examination. Whole-genome sequencing data revealed an ST59 CA-MRSA strain encoding PVL and SCCmec IV. Linezolid was administered in this case, and the patient recovered, with no signs of relapse during the one-year follow-up. We present the first case of PVL-positive ST59 CA-MRSA meningitis, with severe manifestations in China.

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“…Until recently, most cases have been caused by methicillin-susceptible S aureus strains. There are now an increasing number of reports of severe infections attributed to methicillin-resistant strains of S aureus (Pereira et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

Okello

Achieng

Mwachari

et al. 2020

Preprint

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Staphylococcus aureus is a leading cause of hospital and community acquired infections globally. Surveillance of prevalence and antibiotic susceptibility patterns is important to ensure appropriate antibiotic prescription. The aim of this study was to determine the prevalence and susceptibility patterns of Staphylococcus aureus isolated from clinical specimens in a tertiary referral and training hospital.A retrospective study was conducted at the Mater Misericordiae Hospital, Nairobi.It involved analyzing records of specimens analyzed between January 2014 and December 2018. Strains phenotypically resistant to <3 non β-lactam antimicrobial categories were defined as non-multidrug-resistant MRSA (nmMRSA) and strains that were resistant to ≥3 non-β-lactam antimicrobial groups were defined as multidrug-resistant MRSA (mMRSA). A specimen was categorized as Penicillin susceptible (PSSA) if susceptible to Penicillin and Oxacillin, MSSA if resistant to Penicillin and susceptible to Oxacillin, and MRSA if resistant to Oxacillin and Penicillin.ResultsPSSA accounted for 60.85%, (401/659)of S.aureus cultured.The prevalence of MSSA was 38.54%(254/659).MRSA was the least prevalent.(0.61%,4/659).No multi-drug Methicillin resistant S. aureus were isolated in the five-year period.PSSA accounted for 60.85%(401/659)of all S.aureus isolates.100% of MRSA isolated was sensitive to Vancomycin, Linezolid, Tigecycline, Tetracycline and Rifampicin. MRSA was resistant to Clindamycin and Erythromycin.Conclusion;The prevalence of MRSA was low compared to previous studies.All strains isolated were non-multidrug resistant.There was no resistance to Vancomycin detected.Penicillins are still a viable option in the treatment of majority of S.aureus infections in our setting.

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Methicillin resistantStaphylococcus aureusmeningitis

Cited by 6 publications

References 9 publications

An observational study for evaluation of antibiotic utilization and growing resistance against antibiotics in pediatric patients suffering from meningitis in a tertiary care hospital

An observational study for evaluation of antibiotic utilization and growing resistance against antibiotics in pediatric patients suffering from meningitis in a tertiary care hospital

<p>Community-Acquired Methicillin-Resistant <em>Staphylococcus aureus</em> ST59 in a Chinese Adult with Meningitis: A Case Report from China</p>

Prevalence and antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at the Mater Hospital Nairobi, Kenya.

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