Methicillin-Resistant<i>Staphylococcus aureus</i>ST398, Italy

Soavi, Laura; Stellini, Roberto; Signorini, Liana; Antonini, Benvenuto; Pedroni, Palmino; Zanetti, Livio; Milanesi, B; Pantosti, Annalisa; Matteelli, Alberto; Pan, Angelo; Carosi, Giampiero

doi:10.3201/eid1602.091478

Cited by 37 publications

(29 citation statements)

References 9 publications

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“…A number of patients with soft tissue and skin infections and musculoskeletal infections caused by the ST398 S. aureus lineage have been reported [12,13]. A fatal case of necrotizing pneumonia was reported, where the causative pathogen was PVL-gene-positive ST398 MSSA [14].…”

Section: Discussionmentioning

confidence: 96%

A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan

Koyama

Sanui

Saga

et al. 2015

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 96%

A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan

Koyama

Sanui

Saga

et al. 2015

Journal of Infection and Chemotherapy

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“…Both studies were conducted at the Manerbio Hospital, a local hospital with 250 beds, serving a population of approximately 120.000 inhabitants. This area was chosen for the studies because a case of LA-MRSA infection was detected in 2008 [18], and because livestock farming is one of the main economical activities of this area, located in Lombardy, the region with the highest pig farming density in Italy (Figure 1) [21]. …”

Section: Methodsmentioning

confidence: 99%

“…In the study previously cited, MRSA carriage in Italian veterinarians was found to be 54% [14]. Two cases of serious infections due to LA-MRSA were described in Italian farmers in the Lombardy region: a man working on a pig farm who developed cellulitis and pyomiositis of the buttock and a man working on a dairy farm who developed necrotizing fasciitis of the neck [17,18]. …”

Section: Introductionmentioning

confidence: 99%

Livestock-associated methicillin-resistant Staphylococcus aureus responsible for human colonization and infection in an area of Italy with high density of pig farming

et al. 2013

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BackgroundLivestock-Associated MRSA (LA-MRSA) belonging to ST398 lineage, common among pigs and other animals, emerged in Central and Northern Europe, becoming a new risk factor for MRSA among farm workers. Strains belonging to ST398 can be responsible for human colonization and infection, mainly in areas with high livestock-farming. The aim of this study was to investigate the occurrence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) human colonization and infections in an area of the Lombardy Region (Italy), the Italian region with the highest density of pig farming.MethodsIn the period March-April 2010, 879 nasal swabs were taken from subjects at admission to a local hospital serving an area of the Lombardy Region devoted to agriculture and farming. In the period March 2010-February 2011, all MRSA strains from community-acquired infection (CAI) observed in the same hospital, were collected. Molecular characterization of the isolates included SCCmec typing, spa typing and multilocus sequence typing (MLST).ResultsOut of 879 nasal swabs examined, 9 (1%) yielded MRSA. Five strains were assigned to sequence type (ST)398 (spa t899, 3 isolates; t108 and t2922, 1 isolate each) and were therefore categorized as LA-MRSA. The other 4 isolates were likely of hospital origin. No strains were positive for Panton-Valentine Leukocidin genes. Twenty MRSA isolates were detected from CAI, 17 were from skin and soft-tissue infections and 3 from other infections. An MRSA isolate from otitis externa was t899/ST398 and PVL-negative, hence categorized as LA-MRSA. Four isolates were assigned to t127/ST1. Eight strains were PVL-positive community acquired (CA)-MRSA and belonged to different clones, the most frequent being ST8.ConclusionsIn an area of Italy with high density of pig farming, LA-MRSA is able to colonize the population and rarely to produce infections. Typical CA-MRSA is more common than LA-MRSA among CAI.

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“…Risk factors identified for LA-MRSA in The Netherlands include working in direct contact with animals on farms [68,72,73] and working with live pigs in slaughterhouses [74]. Even though MRSA CC398 is usually associated with asymptomatic colonisation, several cases of infections of variable clinical relevance, ranging from SSTIs to endocarditis, pneumonia and necrotising fasciitis, have been described over the past few years [75][76][77][78][79].…”

Section: Spread Of Ca-mrsa Into Hospitalsmentioning

confidence: 99%

Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods

Stefani

Chung

Lindsay

et al. 2012

International Journal of Antimicrobial Agents

508

421

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Methicillin-ResistantStaphylococcus aureusST398, Italy

Cited by 37 publications

References 9 publications

A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan

A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan

Livestock-associated methicillin-resistant Staphylococcus aureus responsible for human colonization and infection in an area of Italy with high density of pig farming

Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods

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