Methicillin-resistant<i>Staphylococcus aureus</i>Toxic Shock Syndrome

Jamart, Sophie; Denis, Olivier; Deplano, Ariane; Tragas, Georgios; Vandergheynst, Alexandra; Bels, David De; Devriendt, Jacques

doi:10.3201/eid1104.040893

Cited by 20 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of strains carrying the TSST-1 gene belonged to MRSA PFGE type G10-ST5-SCCmec II. This clone is closely related to the "New York-Japan clone," which has been associated with neonatal TSS-like exanthematous disease in Japanese hospitals and with TSS in Belgium (16,17). TSST-1 genes have been found in different staphylococcal pathogenicity islands (25).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Activities of Ceftobiprole, Tigecycline, Daptomycin, and 19 Other Antimicrobials against Methicillin-Resistant Staphylococcus aureus Strains from a National Survey of Belgian Hospitals

Denis

Deplano

Nonhoff

et al. 2006

Antimicrob Agents Chemother

Self Cite

View full text Add to dashboard Cite

The in vitro activities of 22 antimicrobial agents, including ceftobiprole, daptomycin, and tigecycline, against 511 methicillin-resistant Staphylococcus aureus (MRSA) isolates from 112 Belgian hospitals were studied by using the CLSI agar dilution method. Isolates were characterized by pulsed-field gel electrophoresis (PFGE) analysis and by PCR detection of determinants of resistance to aminoglycosides, macrolides-lincosamidesstreptogramins, and tetracyclines. A representative set of isolates with different PFGE genotypes was further characterized by multilocus sequence typing, determination of staphylococcal cassette chromosome mec (SCCmec) type, and multiplex PCR for toxic shock syndrome type 1 (TSST-1) and Panton-Valentine leukocidin genes. MRSA isolates belonged to nine epidemic MRSA clones, of which sequence type 45 (ST45)-SCCmec IV and ST8-SCCmec IV were predominant, accounting for 49 and 20% of isolates, respectively. The distribution of antimicrobial resistance and TSST-1 genes was strongly linked to clonal types. Ceftobiprole, daptomycin, and tigecycline showed high activity against all isolates of these sporadic and epidemic MRSA clones, as indicated by MIC 90 s of 2 mg/liter, 0.5 mg/liter, and 0.25 mg/liter, respectively. The MIC distribution of daptomycin and tigecycline was not different in isolates with decreased susceptibility to glycopeptides or tetracyclines, respectively. Ceftobiprole MICs were not correlated with oxacillin and cefoxitin MICs. These data indicate excellent activity of the newly developed agents ceftobiprole, daptomycin, and tigecycline against MRSA isolates recently recovered from hospitalized patients in Belgium, supporting their therapeutic potential for nosocomial MRSA infections.

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro Activities of Ceftobiprole, Tigecycline, Daptomycin, and 19 Other Antimicrobials against Methicillin-Resistant Staphylococcus aureus Strains from a National Survey of Belgian Hospitals

Denis

Deplano

Nonhoff

et al. 2006

Antimicrob Agents Chemother

Self Cite

View full text Add to dashboard Cite

show abstract

“…7 Reports of TSS caused by MRSA have been relatively rare, but have been increasing in frequency. 8 Although MRSA strains have long been known to carry the genes for toxic shock syndrome toxin 1 and enterotoxins B and C, there is no surveillance system currently tracking the relative incidence of TSS caused by MRSA compared with methicillin-sensitive Staphylococcus aureus (MSSA) and no good data to estimate the relative risk of TSS among those infected with MRSA.…”

Section: How Is Toxic Shock Syndrome Treated?mentioning

confidence: 99%

Nonmenstrual Toxic Shock Syndrome Due to Methicillin-Resistant Staphylococcus aureus

Andrews¹,

Shamshirsaz²,

Diekema³

2008

Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

“…4 With an increase in the occurrence of such a disorder there could be implications in terms of empirical treatment.…”

Section: Methicillin-resistant Staphylococcus Aureus Toxic Shock Syndmentioning

confidence: 99%

Methicillin-resistant Staphylococcus aureus toxic shock syndrome

Walden¹,

Harriet²,

Alyaqoobi³

2008

Journal of Infection

View full text Add to dashboard Cite

Methicillin-resistantStaphylococcus aureusToxic Shock Syndrome

Cited by 20 publications

References 9 publications

In Vitro Activities of Ceftobiprole, Tigecycline, Daptomycin, and 19 Other Antimicrobials against Methicillin-Resistant Staphylococcus aureus Strains from a National Survey of Belgian Hospitals

In Vitro Activities of Ceftobiprole, Tigecycline, Daptomycin, and 19 Other Antimicrobials against Methicillin-Resistant Staphylococcus aureus Strains from a National Survey of Belgian Hospitals

Nonmenstrual Toxic Shock Syndrome Due to Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus toxic shock syndrome

Contact Info

Product

Resources

About