Methicillin-resistant Staphylococcus aureus in HIV-infected patients

Hidrón, Alicia; Kempker, Russell R.; Moanna, Abeer; Rimland, David

doi:10.2147/idr.s7641

Cited by 54 publications

(72 citation statements)

References 148 publications

(265 reference statements)

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“…HIV infected patients are recognized as one of these higher risks groups due to increased rates of both MRSA colonization and infection [11]. The organism's interactions and disease manifestations with the immunocompromised host are expected to be complex and involve defects in innate immunity.…”

Section: Discussionmentioning

confidence: 99%

“…The organism's interactions and disease manifestations with the immunocompromised host are expected to be complex and involve defects in innate immunity. Chemo taxis, neutrophil phagocytosis and intracellular killing are vital steps in host defense against S. aureus [11]. Some studies showed significant dysfunctions concerning these elements in persons with HIV [11].…”

Section: Discussionmentioning

confidence: 99%

“…Chemo taxis, neutrophil phagocytosis and intracellular killing are vital steps in host defense against S. aureus [11]. Some studies showed significant dysfunctions concerning these elements in persons with HIV [11].…”

Section: Discussionmentioning

confidence: 99%

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Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient: A Case Report and Review of the Literature

Henniche¹

2017

SOJMID

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of Algiers. She presented a clinical signs of tamponnade with altered general state. A cardiac ultrasound was realized and found a pericardial effusion of big abundance. A surgical drainage was practiced and a purulent liquid was obtained and sent to the microbiology laboratory. The microscopic examination after coloring in the methylene blue showed very numerous altered polymorphonuclear neutrophils and bacteria in the form of cocci isolated and grouped in heap. The culture was practiced on simple media and enriched in the blood.After 18 hours of incubation, yellowish colonies had appeared. The identification was made by the classic bacteriological methods: microscopic examination after coloring of Gram, test in the catalase, research for the coagulase and test of agglutination (PASTOREX TM STAPH-PLUS for BIO-RAD), finding a strain of Staphylococcus aureus. The antibiotic susceptibility of the isolate was realized and interpreted according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI) on 2011. We noted a resistance to cefoxitin implying a resistance of oxacillin and all the beta lactam agents. The MIC of the oxacillin was 4 µg/ ml. This strain was also resistant to kanamycin, Erythromycin, Clindamycin and Fusidic acid. The MIC of vancomycin was 1.5 µg / ml and this isolate was considered sensitive according to the standards of the CLSI on 2011.The molecular study by a technique of PCR confirmed the Methicillin-resistance. This strain harboured the gene mec A, the agr type III and produced the leucocidine of Penton -Valentine (PVL). The patient was treated with vancomycin by intravenous way in the dose of 3 gms in the daytime. A clinical improvement was quickly obtained.After five days of hospitalization, the patient presented arthritis of the right elbow and the knee with a fever in 38°C. In the articular draining, a purulent liquid was obtained. The direct examination showed altered polymorphonuclear neutrophils AbstractPurulent pericarditis is rarely primitive. It is commonly the spread from an adjacent focus of infection of neighbourhood, pneumonia or empyema particularly. The hematogenous contamination arises most of the time on state of Immuno suppression which it would be necessary to look for if no risk factor is detectable initially. We report a case of purulent pericarditis due to Community AcquiredStaphylococcus Aureus Methicillin-Resistant (CA -MRSA) at a patient with type 2 diabetes and HIV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient: A Case Report and Review of the Literature

Henniche¹

2017

SOJMID

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“…tuberculosis (TB) and methicillin-resistant Staphylococcus aureus (MRSA). [2][3][4] MRSA co-infection is characterized by a high incidence rate. 5 In addition, the emergence of multidrug resistant MRSA markedly increased among HIV patients.…”

Section: Introductionmentioning

confidence: 99%

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

et al. 2016

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We are concerned with the development of novel anti-infectives with dual antibacterial and antiretroviral activities for MRSA/HIV-1 co-infection. To achieve this goal, we exploited for the first time the mechanistic function similarity between the bacterial RNA polymerase (RNAP) "switch region" and the viral non-nucleoside reverse transcriptase inhibitor (NNRTI) binding site. Starting from our previously discovered RNAP inhibitors, we managed to develop potent RT inhibitors effective against several resistant HIV-1 strains with maintained or enhanced RNAP inhibitory properties following a structure-based design approach. A quantitative structure−activity relationship (QSAR) analysis revealed distinct molecular features necessary for RT inhibition. Furthermore, mode of action (MoA) studies revealed that these compounds inhibit RT noncompetitively, through a new mechanism via closing of the RT clamp. In addition, the novel RNAP/RT inhibitors are characterized by a potent antibacterial activity against S. aureus and in cellulo antiretroviral activity against NNRTI-resistant strains. In HeLa and HEK 293 cells, the compounds showed only marginal cytotoxicity.

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“…Staphylococcus aureus has emerged as a significant opportunistic pathogen among HIV and AIDS patients in both nosocomial and community settings, and recent studies have shown greater frequency and morbidity of this organism among HIV positive individuals (Chacko et al, 2009., Hidron et al, 2010). Clinical manifestations ranged from superficial to systemic disease conditions, responsible for high morbidity and mortality rate (Lowry et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Profile of Staphylococcus Aureus Associated With HIV Patients in University Of Maiduguri Teaching Hospital (UMTH), Maiduguri, Borno State

Okwori¹,

Ajayi²,

Ibrahim³

et al. 2014

IOSRJDMS

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Methicillin-resistant Staphylococcus aureus in HIV-infected patients

Cited by 54 publications

References 148 publications

Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient: A Case Report and Review of the Literature

Primary Purulent Pericarditis due to Staphylococcus Aureus Methicillin-Resistant in HIV Infected Patient: A Case Report and Review of the Literature

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

Profile of Staphylococcus Aureus Associated With HIV Patients in University Of Maiduguri Teaching Hospital (UMTH), Maiduguri, Borno State

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