Methimazole‐induced toxic epidermal necrolysis in a 12‐year‐old girl

Ziora, Katarzyna; Oświęcimska, Joanna; Broll-Waśka, Katarzyna; Szczepańska, Maria; Szprynger, Krystyna; Pieniazek, Wojciech; Pindycka-Piaszczyńska, Małgorzata; Sakiel, S; Kawecki, Marek

doi:10.1111/j.1440-1754.2006.00901.x

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…Toxic epidermal necrolysis has been also described in a 12-year-old-girl with hyperthyroidism treated with MMI. 15 Various cases of methimazole-induced hypersensitivity syndrome and immunologic side effects were reported, although the precise mechanisms were not elucidated. [16][17][18] An observational clinical study showed that nearly 20% of 100 children treated with MMI developed adverse effects, mainly skin eruptions and arthralgia.…”

Section: Discussionmentioning

confidence: 99%

Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy

Arrigo

Cutroneo

Vaccaro

et al. 2016

Int J Immunopathol Pharmacol

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We reported a case of an 11-year-old girl admitted to our hospital for goiter, tachycardia, sweating, and visible and palpable thyroid. Thyroid function tests revealed a low thyrotropin level (<0.004 mIU/L) and elevated free thyroxine level (3.4 ng/ dL) diagnosed with Graves' disease and treated with methimazole. This anti-thyroid drug is recommended as first-line treatment in children with Graves' disease because it produces minor adverse effects with respect to propylthiouracil. She developed a lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy. The symptoms resolved after discontinuation of methimazole and treatment with an antihistamine and a corticosteroid. Furthermore, the treatment was changed to propylthiouracil without any adverse effects. According to current literature this is the first case of cutaneous figurate erythema related to methimazole, different from other well-known reactions such as skin eruption or urticaria.

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Section: Discussionmentioning

confidence: 99%

Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy

Arrigo

Cutroneo

Vaccaro

et al. 2016

Int J Immunopathol Pharmacol

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“…Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe skin and mucous membrane reactions often associated with medication use [5]. While there have been no prior reports of SJS/TEN linked to preoperative iodine solutions, there have been four documented cases of these conditions resulting from methimazole therapy in pediatric patients [6,7]. Notably, in those instances, the patients were actively taking methimazole when SJS/TEN developed [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…While there have been no prior reports of SJS/TEN linked to preoperative iodine solutions, there have been four documented cases of these conditions resulting from methimazole therapy in pediatric patients [6,7]. Notably, in those instances, the patients were actively taking methimazole when SJS/TEN developed [6,7].…”

Section: Introductionmentioning

confidence: 99%

Toxic Epidermal Necrolysis Secondary to Iodine Versus Methimazole in a Pediatric Patient With Complex Autoimmune Disease

Smaha,

Prosser,

Chan

2024

Cureus

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We report a case of a 17-year-old girl who developed toxic epidermal necrolysis (TEN) secondary to preoperative iodine administration before thyroidectomy for Graves' disease. Past medical history was significant for COVID-19 and multisystem inflammatory syndrome in Children (MISC-C), with subsequent diagnoses of type 1 diabetes mellitus (T1DM), Addison disease, and Graves' disease. Her Graves disease was initially managed with methimazole. While there are reported cases of Stevens-Johnson syndrome (SJS) and TEN due to methimazole, the patient had discontinued methimazole over one month prior. Therefore, she likely represents the first case of TEN reported secondary to potassium iodide solution in a pediatric patient. Given the rarity of TEN in pediatric patients, our case highlights the challenges in managing complex autoimmune conditions and underscores the importance of careful medication choices in such cases.

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Hypersensitivity Reactions to Drugs

Abu-Hilal

Shear

2019

Harper's Textbook of Pediatric Dermatology

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Methimazole‐induced toxic epidermal necrolysis in a 12‐year‐old girl

Abstract: Abstract:We report a 12-year-old girl with hyperthyreosis who presented methamazole-induced toxic epidermal necrolysis (TEN). The patient's past history suggests a presence of autoimmune disease. To our knowledge it is the first report describing such an adverse effect of methimazole.

Cited by 8 publications

References 5 publications

Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy

Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy

Toxic Epidermal Necrolysis Secondary to Iodine Versus Methimazole in a Pediatric Patient With Complex Autoimmune Disease

Hypersensitivity Reactions to Drugs

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