Methionine Hydroxy Analog: Varying Levels for Lactating Cows

Polan, C.E.; Chandler, P.T.; Miller, C.N.

doi:10.3168/jds.s0022-0302(70)86264-6

Cited by 72 publications

(19 citation statements)

References 13 publications

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“…Four treatment groups were found to be outliers based on this screening criterion (Polan et al, 1970;Hansen et al, 1991;Girard et al, 2005;Lara et al, 2006; Table 2). Two of these treatment groups were supplemented with HMTBa, 1 was supplemented with Smartamine, and 1 was supplemented with Mepron.…”

Section: Database Descriptionmentioning

confidence: 99%

Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine

Zanton¹,

Bowman²,

Vázquez-Añón³

et al. 2014

Journal of Dairy Science

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The objectives of our study were to evaluate the productive response to methionine supplementation in lactating dairy cows and to define a relationship between metabolizable Met (MP Met) intake and production. A database of 64 papers meeting the selection criteria was developed evaluating postruminally infused dl-methionine (9 papers with 18 control diets and 35 treatment comparisons), 2-hydroxy-4-methylthio butanoic acid (HMTBa) provided as either a liquid or Ca salt form (17 papers with 34 control diets and 46 treatment comparisons), Mepron (Evonik Industries, Essen, Germany; 18 papers with 35 control diets and 42 treatment comparisons), and Smartamine (Adisseo Inc., Antony, France; 20 papers with 30 control diets and 39 treatment comparisons). Dietary ingredients and their accompanying nutritional compositions as described in the reports were entered into the Cornell-Penn-Miner software to model the diets and to predict nutrients that were not reported in the original publication. Data were analyzed using a weighted analysis of response to supplementation compared with the intraexperiment control, as well as through a regression analysis to changing dietary MP Met. Data included in the analysis were from experiments published between 1970 and 2011 with cows supplemented with between 3.5 and 67.9 g of Met or its equivalent from HMTBa. Cows supplemented with Smartamine consumed more, whereas cows supplemented with Mepron consumed less DM compared with controls. Milk yield did not significantly respond to Met supplementation, although it tended to increase for cows supplemented with HMTBa and Mepron. Milk protein yield was increased due to supplementation from all sources or from infusion, and protein concentration was greater for all supplements or infusion of dl-Met, except for cows supplemented with HMTBa. Irrespective of Met source, milk protein yield increased 2.23 g of protein/g of MP Met until reaching the breakpoint. Milk fat yield was increased for Mepron and HMTBa, whereas milk fat concentration was increased for infused dl-Met and for cows supplemented with HMTBa. Based on regression analysis, response of milk fat yield to Met supplementation was not different for infused dl-Met, Mepron, and Smartamine (1.87 g of fat/g of MP Met), whereas the response to HMTBa was significantly greater at 5.38 g of fat/g of MP Met.

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Section: Database Descriptionmentioning

confidence: 99%

Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine

Zanton¹,

Bowman²,

Vázquez-Añón³

et al. 2014

Journal of Dairy Science

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“…Reported effects of HMTBA provision on milk production and composition are variable (Polan et al, 1970;Piepenbrink et al, 2004;St-Pierre and Sylvester, 2005). Such variation may reflect differences in the amount absorbed or the responsiveness of the cows to additional Met.…”

Section: Whole Bodymentioning

confidence: 99%

“…The hydroxy analog of methionine, 2-hydroxy-4-(methylthio)butanoate (HMTBA), has long been proposed as a means to provide Met and increase milk and protein yields of dairy cows fed rations limited in Met (Polan et al, 1970). The analog HMTBA is more resistant to rumen microbial degradation than l-Met (Belasco, 1972), but estimations of postrumen availability of HMTBA vary greatly.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of 2-hydroxy-4-(methylthio)butanoate (HMTBA) in lactating dairy cows

Lapierre

Vázquez-Añón²,

Parker³

et al. 2011

Journal of Dairy Science

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The objectives of the current study were to determine the fate and contribution to Met kinetics of 2-hydroxy-4-(methylthio)butanoate (HMTBA) at the whole-body, splanchnic, and mammary levels. Four multicatheterized cows (31.3 kg of milk/d; 17.7 kg of DMI/d) were used in a crossover design, with two 1-wk periods, to determine the metabolic fate of HMTBA and its effect on Met metabolism. Over the last 2 d of each period, cows were infused, via a jugular vein, with saline or HMTBA (Alimet, Novus International Inc., St. Louis, Mo) at the rate of 36 g/d. During the last 8h, the HMTBA infusion was substituted by equimolar [1-(13)C]HMTBA (8.79 mmol/h) and l[methyl-(2)H(3)]Met (1.31 mmol/h) was infused in all cows. During the last 5h, hourly samples (n=6) were collected to determine plasma flows plus the isotopic enrichments (IE) and concentrations of HMTBA ((13)C) and Met (both (13)C and (2)H(3)) in plasma from an artery plus portal, hepatic, and mammary veins. The IE of [(13)C] and [(2)H(3)]Met were also determined in milk protein taken over the last 1h of infusion in HMTBA-infused cows. The infused HMTBA increased whole-body plasma flux of Met by 6.5 mmol/h (from 17.9 to 24.4 mmol/h). Based on enrichments of (13)C-labeled Met, 3.8 mmol/h of Met flow through plasma was derived directly from HMTBA. These 2 estimates accounted for between 43 to 74% of the HMTBA dose infused, contributing to increased whole-body Met availability. Although the portal-drained viscera, liver, and mammary gland (MG) extracted 11, 37, and 3.4%, respectively, of the infused HMTBA, tissue net Met fluxes were either unchanged (portal-drained viscera, MG) or even reduced (liver: -7.9 vs. -2.4±0.6 mmol/h). Therefore, net postsplanchnic supply of Met decreased from 7.0 to 2.9 mmol/h between control and HMTBA-infused cows, compared with needs for milk protein secretion of 7.6 and 8.1 mmol/h, respectively. The HMTBA provided directly 15% of the Met required for milk protein secretion, with 0.2 mmol/h synthesized within the MG, whereas 1.1 mmol/h originated from Met produced in other tissues and transported to the MG through blood circulation. Most of the remainder needed by the MG arose from unlabeled Met released from protein breakdown in extra-splanchnic tissues and that was not reused to support intracellular protein synthesis, as this function was performed by Met synthesized from HMTBA in situ. Absorbed HMTBA, therefore, both produces and spares Met for use by the MG.

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“…), mais aussi, beaucoup moins fréquemment toutefois, sur la quantité de lait produite (Bishop, 1971;Stanley & Toma, 1977;Jenny et al, 1980). Ces effets ont cependant été assez souvent nuls (Burgos & Oison, 1970;Wallenius & Whitchurch, 1975) et parfois négatifs (Polan et al, 1970;Laurent & Vignon, 1972 (Chalupa, 1975 (Lundquist et aL, 1982 (Rémond, 1988). Cela montre une absorption intestinale au moins partielle de la mé-thionine distribuée puisque Schwab et al (1988) (Casper et al, 1987;Illg et al, 1987; (Williams ei al., 1970;Papas et al, 1984a et b;Yang et al, 1986;Rémond, 1988), aucune modification du taux protéique du lait ou des quantités de lait ou de protéines produites n'a été enregistrée.…”

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Effet de l'apport de D,L méthionine, protégée de sa dégradation dans le rumen, aux vaches laitières pendant le tout début de la lactation

Rémond¹,

Bony²,

Garel³

et al. 1989

Ann. Zootech.

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Résumé — Dans 3 essais qui se sont déroulés pendant les 6 premières semaines de la lactation, l'effet de la complémentation des rations de total) was studied in 3 trials carried out during the first 6 weeks of lactation. In each trial, cows were divided into 2 groups, one of which was supplemented with methionine supplied in decreasing quantities between each of the 3 successive periods of 2 weeks : 20 g, 12 g and 6 g in trials 1 and 2 respectively and, on an average, 18 g, 10 g and 5 g in trial 3 where the quantities offered were individually adjusted to the expected milk production. The basal diet comprised grass silage fed ad libitum and hay fed in limited amounts in trials 1 and 2 and maize silage in limited amounts in trial 3. In the 3 trials, concentrate was offered in limited quantities adjusted for each cow to its expected milk production. The supply of protected D,L methionine on average did not modify milk production, milk composition, feed intake (trials 1 and 2) or liveweight variations during the 6 experimental weeks.

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Methionine Hydroxy Analog: Varying Levels for Lactating Cows

Cited by 72 publications

References 13 publications

Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine

Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine

Metabolism of 2-hydroxy-4-(methylthio)butanoate (HMTBA) in lactating dairy cows

Effet de l'apport de D,L méthionine, protégée de sa dégradation dans le rumen, aux vaches laitières pendant le tout début de la lactation

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