2012
DOI: 10.2174/1875044301205010039
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Methionine Restriction and Modification of Epithelial Tight Junction Barrier Function and Permeability

Abstract: Abstract:It is well known that caloric restriction leads to an increased longevity by forestalling age-related diseases. Dietary restriction of methionine also renders similar benefits. In this review, we report studies on the effect of methionine restriction on epithelial barrier function in a renal epithelial LLC-PK 1 cell, a rodent gastrointestinal model and a clinical trial using Crohn's patients. In LLC-PK 1 cell culture, a reduction of culture medium methionine by 80% resulted in altered tight junctional… Show more

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