Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review

Metabolomic Profiling of Cardiac Fibrosis and Steatosis in Women With or at Risk for HIV

“…Methionine sulfoxide, a byproduct of oxidative stress that may modulate signal transduction pathways, 49 has been implicated in experimental models of myocardial injury 50 and was linked to abnormal diastology in a general population sample. 51 Taurine, a sulfur amino acid involved in bile acid and taurine metabolism pathways, has shown increased circulating levels in patients with HF as compared with controls, signaling increased protein turnover.…”

Melatonin treatment improves postharvest quality and regulates reactive oxygen species metabolism in “Feizixiao” litchi based on principal component analysis

“…Moreover, the PPO gene downregulation was observed for the melatonin-treated litchi samples. On the contrary, several studies have shown that the Msr-related genes regulated oxidative stress by mediating sulfoxylation of methionine, participated in the redox regulation in the organisms ( Jiang et al, 2017 , 2018 ; Moskovitz and Smith, 2021 ), and also repaired oxidatively damaged protein ( Aussel and Ezraty, 2021 ; Xiao et al, 2021b ).…”

The redox cycling of STAT2 maintains innate immune homeostasis

“…It has been reported that various conditions, such as aging, neurodegenerative diseases, liver and kidney toxicity, cancer, hearing loss, and cardiovascular disease, cause methionine oxidation and impair the MRS system (Moskovitz and Smith, 2021). However, because of the lack of analytical tools for detecting and quantitating the MetO content of individual proteins, the physiological and pathological roles of methionine oxidation remain poorly understood.…”