Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

Abstract

ABBREVIATIONS: AKR, aldo-keto reductase; AOX1, aldehyde oxidase 1; AUC, area under the curve; CL int , intrinsic clearance; C max , maximum plasma concentration; DTT, dithiothreitol; HIC, human intestinal cytosol; HIM, human intestinal microsomes; HLC, human liver cytosol; HLM, human liver microsomes; HRC, human renal cytosol; HRM, human renal microsomes; LC-MS/MS, liquid chromatography-tandem mass spectrometry; MNA, N-methylnicotinamide; MSR, methionine sulfoxide reductase; NSAID, nonsteroidal anti-inflammatory drug; SDR, short-chain dehydrogenases/reductases; TXN, thioredoxin; TXNR, thioredoxin reductase; T max , time of maximum plasma concentration This article has not been copyedited and formatted. The final version may differ from this version.