Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex

Varanasi, Sridhar; Chi, J.; Stephens, Robert L.

doi:10.1016/s0014-2999(01)01579-5

Cited by 1 publication

(1 citation statement)

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“…For example, TRH is also known to play a role in regulating mood (Sun et al, 2010), arousal (Hara et al, 2009), cognition (Molchan et al, 1990), anxiety (Gutierrez-Mariscal et al, 2008), and motor coordination (Pitts et al, 1995; Kinoshita et al, 1998). Additionally, some of the peripheral effects of TRH and its analogs include the ability to increase insulin absorption in the pancreas (Koo et al, 2011), regulation of motility (Varanasi et al, 2002) and acid secretion (Tache et al, 1980) in the gastrointestinal tract, ionotropic support in the heart (Jin et al, 2004), and regulation of hair growth (Gaspar et al, 2010). TRH has also been demonstrated to exert trophic actions in lower motor neurons of the spinal cord (Van den Bergh et al, 1991), and pro-TRH gene expression has been shown to play a role in preventing neuronal apoptosis in the CNS.…”

Section: Introductionmentioning

confidence: 99%

The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases

Daimon¹,

Chirdon²,

Maudsley³

et al. 2013

AJAD

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Thyrotropin releasing hormone (TRH) is primarily known as the central regulator of the hypothalamic-pituitary-thyroid (HPT) axis. However, TRH also exerts a variety of central nervous system effects independent from its activity in the HPT axis. With advancing age, decreases in TRH synthesis, expression, and activity have been demonstrated. Associated with this emerging evidence suggests that TRH is implicated in neurodegenerative diseases of aging, including Alzheimer’s disease and Parkinson’s disease. TRH and its synthetic analogs have been recognized as trophic factors in neurons of the diencephalon and spinal cord, and as neuroprotectants against oxidative stress, glutamate toxicity, caspase-induced cell death, DNA fragmentation, and inflammation. In this review, we will provide an overview of some of the roles of TRH, outside of the HPT axis, associated with pathological aging and neurodegeneration and we shall discuss the potential of TRH and TRH analogs for the treatment of neurodegenerative diseases.

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