Method for Analysis of Polymer-Supported Organic Compounds Using Mass Spectrometry Direct Insertion

Chavez, Daniel; Ochoa, A.; Madrigal, Domingo; Castillo, M.; Espinoza, Karla; Gonzalez, Tania Valdes; Velez, Ernesto; Melendez, Javier; García, and J. D.; Rivero, Ignacio A.

doi:10.1021/cc0200540

Cited by 11 publications

(15 citation statements)

References 17 publications

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“…All library members were successfully synthesized as evidenced by LC-MS and a simple method based on Direct-Insertion mass spectrometry with electronic impact was developed in our group [14]. All library members were successfully synthesized as evidenced by LC-MS and a simple method based on Direct-Insertion mass spectrometry with electronic impact was developed in our group [14].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Metallothionein-Mimic Decapeptides with Heavy Atom Signaling Properties

Dı́az-Garcı́a

Rivero

Gonzalez³

2006

CCHTS

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The automated parallel solid-phase synthesis of a 17-member library of metallothionein-mimic decapeptides carrying a Lariat ether group is described. The peptides were synthesized in good yield and the identity and quality of each product were performed by mass spectrometry and IR. Subsequently, in the presence of europium(III) ions as fluorescent reporter, each compound was screened, both attached to the resin and cleaved off, for their sensing behavior towards metal ions (Cd(2+),Hg(2+), Cu(2+), Mg(2+) and Ca(2+)) using fluorimetric techniques. Several of these Cys-enriched synthetic peptides showed surprisingly low detection limits for Cd(2+) and Hg(2+). The analytical potential of these metallothionein-mimic decapeptides as metal ion recognition materials for sensor development is outlined. Finally, the sensing response mechanism, based on an energy transfer process and a metal ion allosteric interaction, is proposed.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Metallothionein-Mimic Decapeptides with Heavy Atom Signaling Properties

Dı́az-Garcı́a

Rivero

Gonzalez³

2006

CCHTS

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“…The molecular characterization of the MWCNTamide was carried out with direct insertion technique proposed by Chavez et al 19 using a mass spectrometer (Thermo Finnigan Polaris Q).…”

Section: Amidation Reaction To Produce Multi-wallmentioning

confidence: 99%

Molecular Assembly of Multi-Wall Carbon Nanotubes with Amino Crown Ether: Synthesis and Characterization

Espinoza-Gómez

Somanathan

et al. 2011

j nanosci nanotechnol

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Synthetic methodology and physicochemical characterization of multi-wall carbon nanotubes (MWCNTs) functionalized with a crown ether molecule is reported. The MWCNTs were synthesized by spray pyrolysis technique using toluene as carbon source and ferrocene as catalyst. The nanotubes were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Oxidation of MWCNTs was carried out by 8 h of sonication in a mixture of sulfuric and nitric acid (3:1). The MWCNT-COOH was amidated with 4-aminobenzo-15-crown-5 under mild reaction conditions using N,N'-dicyclohexylcarbodiimide and dimethylaminopyridine as catalyst and dimethylformamide as solvent, at room temperature for 24 h. The amidation product was characterized by scanning electron microscopy, infrared spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy and a mass spectrometry study to determine the fragmentation pattern being m/z 309, 177 and 149 the most important ions.

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“…For infrared spectroscopic studies related compounds, see: Grice et al (2000); Yan & Yan (2001). For mass spectroscopy of related compounds, see: Chavez et al (2003); Olivas et al (2008); Madrigal et al (2006). For examples of OÁ Á ÁO interactions, see: Raghavaiah et al (2006), and for a comprehensive theoretical treatment, see: Ni et al (2004).…”

Section: Related Literaturementioning

confidence: 99%

Benzene-1,3,5-triyl tris(methanesulfonate)

2010

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Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.005 Å; R factor = 0.055; wR factor = 0.177; data-to-parameter ratio = 22.0.In the molecule of the title compound, C 9 H 12 O 9 S 3 , the two methanesulfonate groups re located one above and one below the ring plane. The C-O-S angle range is 119.3 (2)-121.1 (2) . This conformation is different from that of the benzene analog 1,2,5-tris(p-toluenesulfonate), which is a three-legged 'table' with all fragments of the p-toluenesulfonate on top of the benzene ring. In the crystal, the supramolecular aggregation is completed by the presence of C-HÁ Á ÁO hydrogen bonds. Related literature ExperimentalCrystal data

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Method for Analysis of Polymer-Supported Organic Compounds Using Mass Spectrometry Direct Insertion

Cited by 11 publications

References 17 publications

Synthesis of Metallothionein-Mimic Decapeptides with Heavy Atom Signaling Properties

Synthesis of Metallothionein-Mimic Decapeptides with Heavy Atom Signaling Properties

Molecular Assembly of Multi-Wall Carbon Nanotubes with Amino Crown Ether: Synthesis and Characterization

Benzene-1,3,5-triyl tris(methanesulfonate)

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