Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization

Romano, Vito; Steger, Bernhard; Brunner, Matthias; Ahmad, Sajjad; Willoughby, Colin E.; Kaye, Stephen B.

doi:10.1097/ico.0000000000000865

Cited by 24 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 7 , 14 Therefore, surgical methods, such as FND, are then recommended to treat mature CoNV. 7 , 10 , 11 During vessel maturation in corneal angiogenesis, pericyte coverage is a histologic indicator of decreasing VEGF dependence. Pericyte recruitment is a fairly rapid process occurring in the majority of CoNV between its onset and keratoplasty.…”

Section: Discussionmentioning

confidence: 99%

“…The results of this study connect biomicroscopic clinical assessment of CoNV with functional angiographic properties of CoNV. Intravenous dye leakage may be associated with incomplete pericyte coverage of CoNV as a promising predictor of the CoNV treatment response to anti-VEGF agents and serve as a clinically useful guide to the most appropriate therapeutic approach in the preconditioning treatment of CoNV, specifically between surgical (e.g., fine needle diathmery) 11 and medical options. 28 …”

Section: Discussionmentioning

confidence: 99%

“… 8 , 9 We have shown, that angiography-guided selective application of FND limited to afferent vascular branches of CoNV is an effective method to reduce mature CoNV while carrying less potential to damage to the limbal epithelial stem cell niche and the peripheral corneal stroma. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography

Palme

Romano

Brunner

et al. 2018

Trans. Vis. Sci. Tech.

Self Cite

View full text Add to dashboard Cite

PurposeCorneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV.MethodsIn a prospective cross-sectional study patients with CoNV of variable but known duration and etiology were included. All cases were clinically staged according to a simplified three-grade scale as active, inactive, and regressed and assessed using color photography, anterior-segment optical coherence tomography, and fluorescein and indocyanine green (ICG) angiography. Outcome parameters included age and depth of CoNV, perfusion times and time to leakage of fluorescein and ICG.ResultsForty eyes of 39 patients with CoNV were included, active (14), inactive (22), and regressed CoNV (4). There were significant associations between the time to fluorescein or ICG leakage and clinical staging of CoNV (R2 = 0.24; P = 0.0011, and R2 = 0.3; P = 0.0001). In addition, there was a significant association between the time to fluorescein leakage and the age of CoNV (R2 = 0.32; P = 0.0002). ICG leakage within 10 minutes was observed significantly more frequently in active than the inactive group and was not observed in regressed cases (P < 0.0001).ConclusionsSimplification of the staging of CoNV to active, inactive, and regressed to is significantly associated with the time to extravascular leakage of fluorescein and indocyanine and may be useful to guide the selection of appropriate treatments.Translational RelevanceThe association between clinical and angiographic characteristics of CoNV may provide guidance to the treatment approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography

Palme

Romano

Brunner

et al. 2018

Trans. Vis. Sci. Tech.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, angiography-guided FND was used to treat afferent vessels [ 62 , 63 ]. This approach can selectively treat feeder vessels with minimal thermal energy applied to the cornea and reduced risk of stromal haemorrhage [ 64 ].…”

Section: Treatmentsmentioning

confidence: 99%

Therapeutic approaches for corneal neovascularization

2017

View full text Add to dashboard Cite

Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid administration, laser treatment, cautery, and fine needle diathermy. Since the imbalance between proangiogenic agents and antiangiogenic agents primarily mediate the process of corneal neovascularization, recent therapies are intended to disrupt the different steps in the synthesis and actions of proangiogenic factors. These approaches, however, are only partially effective and may lead to several side effects. The aim of this article is to review the most relevant treatments for corneal neovascularization available so far.

show abstract

“…37 The potential adverse effects of FND should be taken into account and diathermy should be limited to the afferent vessels (selective FND). 123,124 Some corneal changes after FND have been welldescribed, whereas others such as cellular changes are less understood.…”

Section: Photodynamic Therapymentioning

confidence: 99%

The Management of Corneal Neovascularisation – Update on New Clinical Data and Recommendations of Treatment

Spiteri¹,

Romano²,

Brunner³

et al. 2016

European Ophthalmic Review

Self Cite

View full text Add to dashboard Cite

Vascularisation of the cornea may occur as a sight-threatening response to various insults to the cornea, such as infection, trauma and inflammation, and is a well-recognised risk factor for rejection and subsequent failure of corneal grafts. Various different treatment modalities have been used in the past, with varying levels of success. In this review, we discuss the pathogenesis of corneal neovascularisation, look at recent advances in the assessment of these patients and give an overview of currently available treatment options, both medical and surgical. We also discuss current experimental treatment for corneal neovascularisation, such as gene therapy, which may provide further treatment options in the future.

show abstract

Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization

Abstract: The described method for angiographically guided assessment of CoNV is a useful approach for guiding the medical and surgical treatment of CoNV.

Cited by 24 publications

References 25 publications

Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography

Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography

Therapeutic approaches for corneal neovascularization

The Management of Corneal Neovascularisation – Update on New Clinical Data and Recommendations of Treatment

Contact Info

Product

Resources

About