Method for improving photodynamic diagnosis and surgery of bladder tumours using cystoscopes

Lindvold, Lars René; Hermann, Gregers G.

doi:10.1117/12.2078780

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Only the light source is tailor-made but with a light guide connection identical to that used in fluorescence assisted cystoscopy (PDD). Consequently, a user familiar with conventional photodynamic diagnosis of bladder tumours will immediately be able to use the new light source A detailed description of this light source can be found in a previous publication (Lindvold and Hermann 2015). In short, this light source is based on high power Luminus Devices PT-121-TE with a centre wavelength of 525 nm.…”

Section: The Led Light Sourcementioning

confidence: 99%

An optical method for reducing green fluorescence from urine during fluorescence-guided cystoscopy

Lindvold

Hermann

2016

Methods Appl. Fluoresc.

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Photodynamic diagnosis (PDD) of bladder tumour tissue significantly improves endoscopic diagnosis and treatment of bladder cancer in rigid cystoscopes in the operating theatre and thus reduces tumour recurrence. PDD comprises the use of blue light, which unfortunately excites green fluorescence from urine. As this green fluorescence confounds the desired red fluorescence of the PDD, methods for avoiding this situation particularly in cystoscopy using flexible cystoscopes are desirable. In this paper we demonstrate how a tailor made high power LED light source at 525 nm can be used for fluorescence assisted tumour detection using both a flexible and rigid cystoscope used in the outpatient department (OPD) and operating room (OR) respectively. It is demonstrated both in vitro and in vivo how this light source can significantly reduce the green fluorescence problem with urine. At the same time this light source also is useful for exciting autofluorescence in healthy bladder mucosa. This autofluorescence then provides a contrast to the sensitized fluorescence (PDD) of tumours in the bladder.

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Section: The Led Light Sourcementioning

confidence: 99%