Due to the rapid growth in the world population, there has been an increase in energy consumption globally. The problem of efficient energy use becomes more relevant and stimulates research and development of new energy and resource-saving technologies. This task is becoming more complicated when the other factors are accounted for, resulting in multiple-factor trade-offs, such as the water-energy-food nexus. This paper highlights the main points for the development of Process Integration in the Commonwealth of Independent States (CIS) countries. It shows the main achievements in the field to date and demonstrates the scientific schools that are working on these problems. A comprehensive review of modern approaches and methods, which are now being developed or have been recently developed, was done. It shows a research gap in Process Integration in CIS and other leading countries. It demonstrates the significant research potential as well as practical applications. The main challenges in process systems engineering and for the sustainable development of industrial energy systems are also discussed. Industry digital transformation, energy transition, circular economy, and stronger energy and water integration are pointed out as priorities in analysis, design, and retrofit of society in the future. A state-of-the-art review in the area of integration of continuous and batch processes, mass integration technologies, and process intensification is presented to show the variety of existing approaches. The necessity of Process Integration development in the CIS is shown to be a necessary condition for building a more sustainable society and a resource-efficient economy.