We propose a modeling methodology tailored to predicting the wavelength and power output from a distributed Bragg reflector laser for use in quantum measurements. The relationship between power, wavelength, current, and temperature is acquired with a genetic algorithm (GA). The function set and termination set for GA are determined from the physical mechanisms of laser current, temperature, and output performance. To verify the validity of the method, measured data are divided into a training group and a test group. The test results show that our models can accurately predict the value of power and wavelength at the given current and temperature, with the RMSE of 13.4 μW and 6.0 × 10 −5 nm, respectively. This method can help enhance the output performance of a laser. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.