Method of quantifying 3D strain distribution in skeletal muscle using cine phase contrast MRI

Jensen, Elisabeth; Morrow, Duane A.; Felmlee, Joel P.; Murthy, Naveen S.; Kaufman, Kenton R.

doi:10.1088/0967-3334/36/12/n135

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…One factor might be related to intramuscular alterations (Sejersted and Hargens, 1995 ), however, the location IMP sensor insertion was chosen to provide less variability. Previous modeling studies based on volumetric strain analysis using cine phase contrast MRI (Jensen et al, 2015 ) showed less regional volumetric strain in the superior and middle portion of TA for passive conditions (Jensen et al, 2015 ) and were used to guide sensor placement in this study.…”

Section: Discussionmentioning

confidence: 95%

Intramuscular Pressure of Tibialis Anterior Reflects Ankle Torque but Does Not Follow Joint Angle-Torque Relationship

et al. 2018

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Intramuscular pressure (IMP) is the hydrostatic fluid pressure that is directly related to muscle force production. Electromechanical delay (EMD) provides a link between mechanical and electrophysiological quantities and IMP has potential to detect local electromechanical changes. The goal of this study was to assess the relationship of IMP with the mechanical and electrical characteristics of the tibialis anterior muscle (TA) activity at different ankle positions. We hypothesized that (1) the TA IMP and the surface EMG (sEMG) and fine-wire EMG (fwEMG) correlate to ankle joint torque, (2) the isometric force of TA increases at increased muscle lengths, which were imposed by a change in ankle angle and IMP follows the length-tension relationship characteristics, and (3) the electromechanical delay (EMD) is greater than the EMD of IMP during isometric contractions. Fourteen healthy adults [7 female; mean (SD) age = 26.9 (4.2) years old with 25.9 (5.5) kg/m2 body mass index] performed (i) three isometric dorsiflexion (DF) maximum voluntary contraction (MVC) and (ii) three isometric DF ramp contractions from 0 to 80% MVC at rate of 15% MVC/second at DF, Neutral, and plantarflexion (PF) positions. Ankle torque, IMP, TA fwEMG, and TA sEMG were measured simultaneously. The IMP, fwEMG, and sEMG were significantly correlated to the ankle torque during ramp contractions at each ankle position tested. This suggests that IMP captures in vivo mechanical properties of active muscles. The ankle torque changed significantly at different ankle positions however, the IMP did not reflect the change. This is explained with the opposing effects of higher compartmental pressure at DF in contrast to the increased force at PF position. Additionally, the onset of IMP activity is found to be significantly earlier than the onset of force which indicates that IMP can be designed to detect muscular changes in the course of neuromuscular diseases impairing electromechanical transmission.

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Section: Discussionmentioning

confidence: 95%

Intramuscular Pressure of Tibialis Anterior Reflects Ankle Torque but Does Not Follow Joint Angle-Torque Relationship

et al. 2018

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“…Compared to shear and shear strain eigenvalues, the volumetric strain is an order of magnitude smaller but not zero. The volumetric strain values of the anterior tibialis under passive plantarflexion in humans has been reported (Jensen et al, 2015(Jensen et al, , 2016; the latter studies revealed predominantly positive volumetric strains with a heterogeneous distribution under passive stretch. Jensen et al reported mean values of 0.018 ± 0.026 mm 3 /mm 3 in the most superior muscle slice and 0.26 ± 0.13 mm 3 /mm 3 in the most medial, inferior region (Jensen et al, 2016).…”

Section: Discussionmentioning

confidence: 97%

“…In the current work, implementation of the fast CS VE-PC sequence enabled multi-slice, 3 directional VE-PC acquisitions of sufficiently short duration that it could be tolerated even by the senior cohort. Jensen et al (2015Jensen et al ( , 2016 used sequential acquisition of 2D slices with velocity encoded phase contrast acquisition to compute the volumetric strain tensor under condition of passive plantarflexion. The latter papers noted that acquisition of multi-slice, 3 directional data under conditions of dynamic contractions (e.g., isometric) is more challenging than passive motion due to the requirement of a large number of consistent contractions and suggested the use of faster sequences.…”

Section: Discussionmentioning

confidence: 99%

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

Malis

Sinha

2020

Front. Physiol.

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3D strain or strain rate tensor mapping comprehensively captures regional muscle deformation. While compressive strain along the muscle fiber is a potential measure of the force generated, radial strains in the fiber cross-section may provide information on the material properties of the extracellular matrix. Additionally, shear strain may potentially inform on the shearing of the extracellular matrix; the latter has been hypothesized as the mechanism of lateral transmission of force. Here, we implement a novel fast MR method for velocity mapping to acquire multi-slice images at different % maximum voluntary contraction (MVC) for 3D strain mapping to explore deformation in the plantar-flexors under isometric contraction in a cohort of young and senior subjects. 3D strain rate and strain tensors were computed and eigenvalues and two invariants (maximum shear and volumetric strain) were extracted. Strain and strain rate indices (contractile and in-plane strain/strain rate, shear strain/strain rate) changed significantly with %MVC (30 and 60% MVC) and contractile and shear strain with age in the medial gastrocnemius. In the soleus, significant differences with age in contractile and shear strain were seen. Univariate regression revealed weak but significant correlation of in-plane and shear strain and shear strain rate indices to %MVC and correlation of contractile and shear strain indices to force. The ability to map strain tensor components provides unique insights into muscle physiology: with contractile strain providing an index of the force generated by the muscle fibers while the shear strain could potentially be a marker of lateral transmission of force.

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“…Data processing methods have been described in detail previously (Jensen et al, 2015a). Briefly, the TA muscle was manually segmented from all T2-weighted images (Mimics, Materialise, Leuven, Belgium).…”

Section: Methodsmentioning

confidence: 99%

Characterization of three dimensional volumetric strain distribution during passive tension of the human tibialis anterior using Cine Phase Contrast MRI

Jensen

Morrow

Felmlee

et al. 2016

Journal of Biomechanics

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Intramuscular pressure correlates strongly with muscle tension and is a promising tool for quantifying individual muscle force. However, clinical application is impeded by measurement variability that is not fully understood. Previous studies point to regional differences in IMP, specifically increasing pressure with muscle depth. Based on conservation of mass, intramuscular pressure and volumetric strain distributions may be inversely related. Therefore, we hypothesized volumetric strain would decrease with muscle depth. To test this we quantified 3D volumetric strain in the tibialis anterior of 12 healthy subjects using cine Phase Contrast Magnetic Resonance Imaging. Cine Phase Contrast data were collected while a custom apparatus rotated the subjects’ ankle continuously between neutral and plantarflexion. A T2-weighted image stack was used to define the resting tibials anterior position. Custom and commercial post-processing software were used to quantify the volumetric strain distribution. To characterize regional strain changes, the muscle was divided into superior-inferior sections and either medial-lateral or anterior-posterior slices. Mean volumetric strain was compared across the sections and slices. As hypothesized, volumetric strain demonstrated regional differences with a decreasing trend from the anterior (superficial) to the posterior (deep) muscle regions. Statistical tests showed significant main effects and interactions of superior-inferior and anterior-posterior position as well as superior-inferior and medial-lateral position on regional strain. These data support our hypothesis and imply a potential relationship between regional volumetric strain and intramuscular pressure. This finding may advance our understanding of intramuscular pressure variability sources and lead to more reliable measurement solutions in the future.

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Method of quantifying 3D strain distribution in skeletal muscle using cine phase contrast MRI

Cited by 5 publications

References 34 publications

Intramuscular Pressure of Tibialis Anterior Reflects Ankle Torque but Does Not Follow Joint Angle-Torque Relationship

Intramuscular Pressure of Tibialis Anterior Reflects Ankle Torque but Does Not Follow Joint Angle-Torque Relationship

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

Characterization of three dimensional volumetric strain distribution during passive tension of the human tibialis anterior using Cine Phase Contrast MRI

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