Method to determine stability and recovery of carboprost and misoprostol in infusion preparations

Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study

“…4. The concentration of carboprost methylate were below the LLOQ (50 pg/mL) before the dose and at 2,4,8,10,15,20,30,45,60,90,120,180,240, and 360 min after dosing. The results show that carboprost methylate was released from the suppository and converted to carboprost during absorption and/or in the vagina and blood.…”

“…To date, methyl carboprost and its acid-catalyzed degradation products have been determined in a polymeric controlled-release device by high performance liquid chromatography (HPLC) with UV detection [18]. In addition, carboprost has been determined in a sterile solution and infusion preparation using HPLC with UV and MS detection [19,20]. Green and Bygdeman [21] developed a GC-MS method for the quantification of carboprost and carboprost methylate in plasma, which required multiple step derivatization and was time-consuming.…”

Identification of drugs using FTIR in a case of illegal abortion: A forensic study

“…When misoprostol was crystallized using precipitating agent, polyethylene glycol, square prism shaped crystals were obtained [10]. The exposed medicine in the environment shows the decrease in the active ingredient dosage and increase in inactive degradation products [11] and when the stability of the said medicine is in question, to make it more stable the derivatives such as O-2,3,4,5,6-Pentafluorobenzylhydroxylamine hydrochloride (PFBHA) and 2,3,4,5,6-pentafluorobenzyl bromide (PFBB) are often used with 15(S)-15-methyl PGE2 as internal standard and pentafluorobenzyl (PFB) and pentafluorobenzyl oxime (PFBO) are used for derivatization in GC-MS analysis [12][13][14]. Similarly, to stabilize other prostaglandins, methyl ester /methoxin / tert -butyldimethylsilyl (ME-MO-TBDMS) ether derivatives are used for PGE2, PGD2, 6-keto PGF1α and methyl ester / tert-butyldimethylsilyl (ME-TBDMS) ether derivatives are used for 8-epi-PGF2α and PGF2α [15].…”

Efficacy of Electroacupuncture Combined with Tropisetron in Treating Carboprost Tromethamine-Induced Nausea and Vomiting during Cesarean Section under Lumbar Anesthesia

“…From October 2015 to June 2018, 317 patients undergoing planned cesarean section at Cangzhou Central Hospital were assessed for eligibility. The inclusion criteria were: (1) American Society of Anesthesiologists' (ASA) physical status classes I and II; (2) aged 22-40 years; (3) single pregnancy patients scheduled for elective cesarean delivery; (4) no history of nausea or vomiting in the preceding week; (5) no history of carboprost tromethamine allergy, no contraindication of needling and carboprost tromethamine; (6) no medication with antiemetic or antihistaminic medicines in the 24 h before the surgery; (7) no pregnancy-induced hypertension, no spinal cord block contraindication. The exclusion criteria were: (1) no nausea and vomiting after injected carboprost tromethamine during the operation; (2) patient changed the mode of delivery and did not undergo cesarean section; (3) requiring IV opioids because of complicated or inappropriate spinal anesthesia; (4) nausea and vomiting caused by supine hypotension syndrome and hypotension during operation; (5) having intraoperative blood loss >800 mL; (6) conversion to general anesthesia during surgery; (7) history of gastrointestinal disorder, motion sickness, or ear diseases that might lead to nausea or vomiting.…”

“…Carboprost tromethamine is a synthetic 15-methyl analogue of prostaglandin F2α and has been reported to be effective in 84-96% of cases in the prevention and treatment of persistent hemorrhage due to uterine atony during cesarean section [4]. However, it can shrink the uterine smooth muscle, while at the same time contracting the gastrointestinal smooth muscle, thereby inducing nausea and vomiting that interferes with surgical operation and in severe cases even risking reflux and aspiration [5,6].…”