Method validation parameters for drugs and explosives in ambient pressure ion mobility spectrometry

Sedwick, Victoria; Massey, Monique; Codio, TeAsia; Kanu, Abu B.

doi:10.1007/s12127-017-0221-z

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…Reduced ion mobilities ( K 0 ) were calculated using sample drift time ( t d ) with Equation 1 and an accepted cocaine reduced ion mobility ( K 0,coc ) of 1.160 cm 2 V −1 s −1 with a drift time ( t d,coc ) of 7.967 ms programmed into the instrument 18,19

K_{0} goodbreak= \frac{((), K_{0, italiccoc} t_{d, italiccoc})}{t_{d}}

…”

Section: Methodsmentioning

confidence: 99%

“…The GC column oven began at 30 C, was held for 30 s, increased to 240 C at 50 C/min, and finally held at 240 C for 15 s. The transfer line to the MS was 250 C and the MS was operated in Selective Ion Mode (SIM). More details on the set-up and function of the TESTbed can be found in Collins et al16 2.5 | Data analysisReduced ion mobilities (K 0 ) were calculated using sample drift time (t d ) with Equation 1 and an accepted cocaine reduced ion mobility (K 0,coc ) of 1.160 cm 2 V À1 s À1 with a drift time (t d,coc ) of 7.967 ms programmed into the instrument 18,19.…”

mentioning

confidence: 99%

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Non‐contact detection of fentanyl by a field‐portable ion mobility spectrometer

Fulton

Vaughan

DeGreeff

2022

Drug Testing and Analysis

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Rapid on-site detection of fentanyl is paramount for the safety of law enforcement and other first responders. Due to the opioid epidemic, death by overdose is at an all-time high with fentanyl adulteration as the main assailant. Providing a userfriendly method for the presumptive detection of fentanyl will increase safety for first responders. Ion mobility spectrometry (IMS) provides a quick, affordable, and accurate method for detecting fentanyl. Currently, most methods for detecting fentanyl require manipulation or handling of the highly potent substance. A recent comparative analysis study on the headspace of fentanyl determined N-phenylpropanamide (NPPA) a target analyte for fentanyl enabling vapor detection. Here, we demonstrate the development of a handheld IMS method for vapor detection of the target analyte for fentanyl. An alarm was programmed into the handheld IMS device for the detection of NPPA. The system was able to accurately detect NPPA in samples of reference-grade fentanyl and diluted reference-grade fentanyl, as well as 3.67 mg of fentanyl from samples confiscated from the US border. Common adulterants and over-the-counter drugs were tested and resulted in a false alarm rate of 0 for substances sampled. The limit of detection was determined to be as low as 5 ng of NPPA. Overall, the development of this user-friendly, non-contact method has considerable promise for near real-time non-contact detection of fentanyl increasing safety of first responders.

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