Methodological and Technical Issues for Integrating Functional Magnetic Resonance Imaging Data in a Neuronavigational System

Roux, Franck‐Emmanuel; Ibarrola, Danielle; Trémoulet, M; Lazorthes, Y; Henry, P.; Sol, Jean‐Christophe; Berry, I.

doi:10.1227/00006123-200111000-00025

Cited by 38 publications

(55 citation statements)

References 41 publications

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“…Other functional cortical mapping techniques like functional magnetic resonance imaging (Roux et al, 2001) and magnetic source imaging (Schiffbauer et al, 2001) have recently been investigated as noninvasive presurgical means of identifying eloquent cortical regions. The results have been promising, but to date, the best conclusion is that these methods can guide the surgeon in performing intraoperative stimulation but cannot replace cortical mapping.…”

Section: Discussionmentioning

confidence: 99%

Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping

et al. 2004

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The combination of mapping functional cortical neurons by intraoperative cortical stimulation and axonal architecture by diffusion tensor MRI fiber tracking can be used to delineate the pathways between functional regions. In this study the authors investigated the feasibility of combining these techniques to yield connectivity associated with motor speech and naming. Diffusion tensor MRI fiber tracking provides maps of axonal bundles and was combined with intraoperative mapping of eloquent cortex for a patient undergoing brain tumor surgery. Tracks from eight stimulated sites in the inferior frontal cortex including mouth motor, speech arrest, and anomia were generated from the diffusion tensor MRI data. The regions connected by the fiber tracking were compared to foci from previous functional imaging reports on language tasks. Connections were found between speech arrest, mouth motor, and anomia sites and the SMA proper and cerebral peduncle. The speech arrest and a mouth motor site were also seen to connect to the putamen via the external capsule. This is the first demonstration of delineation of subcortical pathways using diffusion tensor MRI fiber tracking with intraoperative cortical stimulation. The combined techniques may provide improved preservation of eloquent regions during neurological surgery, and may provide access to direct connectivity information between functional regions of the brain.

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Section: Discussionmentioning

confidence: 99%

Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping

et al. 2004

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“…The technique is based on the coupling between cortical neuronal activity and regional cerebral vascular response causing blood oxygen-dependent contrast (7)(8)(9)(10). This approach correlates well with intraoperative mapping (11) and the risk of motor postoperative deficits (4), and it can be used in conjunction with intraoperative localization techniques (12). Functional MR imaging is complementary to, although not a replacement for, these other methods of localization, including intraoperative electrocortical stimulation (2,5).…”

mentioning

confidence: 95%

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

Koçak

Ulmer

Uğurel³

et al. 2009

Radiology

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Purpose:To determine the concurrence of activation in the primary motor cortex, induced by paradigms of active and passive movement of extremities, by using blood oxygen leveldependent functional magnetic resonance (MR) imaging. Materials and Methods:The HIPAA-compliant study was approved by the institutional review board, and written informed consent was obtained from the participating volunteers. Functional MR imaging data were collected from 11 healthy volunteers (four women, seven men; age range, 24 -42 years) during active and passive movements of hand, elbow, shoulder, ankle, knee, and hip. These data were then mapped onto three-dimensional anatomic images. Volumes of activation were determined by using cross-correlation analysis at a coefficient threshold of 0.4 (P Ͻ .01). Regions of interest were drawn in pre-and postcentral gyri based on anatomic criteria. The mean number of activated voxels in the preand postcentral gyri induced by active and passive movements was compared by using Wilcoxon analysis. Concurrence ratios and proportional ratios of activation between active and passive movements were calculated for each somatotopic location.

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“…The impact of intrinsic brain tumors on cortical gray matter has been extensively studied in vivo by means of fMRI [4], magneto-encephalography (MEG) [5] and direct electrical stimulation (ECS) [6]. These studies have clearly demonstrated that intrinsic brain tumors grow by infiltration of surrounding brain parenchyma; functionally important areas can reside within grossly abnormal tissue.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor and Functional MRI Fusion with Anatomical MRI for Image-Guided Neurosurgery

Talos

O’Donnell

Westin

et al. 2003

Lecture Notes in Computer Science

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Abstract. In order to achieve its main goal of maximal tumor removal while avoiding postoperative neurologic deficits, neuro-oncological surgery is strongly dependent on image guidance. Among all currently available imaging modalities, MRI provides the best anatomic detail and is highly sensitive for intracranial pathology. However, conventional MRI does not detect the exact location of white matter tracts or areas of cortical activation. This essential information can be obtained non-invasively by means of diffusion tensor MRI (DT-MRI) and functional MRI (fMRI) respectively. Here we present our initial experience with fMRI and DT-MRI for surgical planning and guidance in ten brain tumor cases.

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Methodological and Technical Issues for Integrating Functional Magnetic Resonance Imaging Data in a Neuronavigational System

Cited by 38 publications

References 41 publications

Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping

Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

Diffusion Tensor and Functional MRI Fusion with Anatomical MRI for Image-Guided Neurosurgery

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