Methodological Approaches to the Definition of Embryo and Teratogenicity in Morphological Experiments

Шаторна, В. Ф.; Harets, V. I.; Ostrovskaya, S.S.; Kononova, I. I.; Krasnov, А.А.

doi:10.26693/jmbs01.01.189

Cited by 2 publications

(4 citation statements)

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“…Classified as a potent poison, lead can have far-reaching effects, leading to toxicity in blood-producing organs and damage to the central and peripheral nervous systems, digestive tract, cardiovascular system, and immune system. Furthermore, it negatively affects the liver and kidneys, disrupts metabolic processes like protein synthesis, and poses risks to fetal development [ 2 , 8 , 30 , 31 , 32 , 33 ]. Its membrane-toxic properties, ability to modify enzyme activity, impact on biochemical processes, bodily accumulation, and persistence in causing harmful long-term effects are well-documented [ 2 , 11 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…In comparison, the impact of lead exposure on female reproduction is even more profound. Lead disrupts menstrual cycles, causing issues like amenorrhea, dysmenorrhea, and menorrhagia, while also diminishing fertility potential, delaying conception, altering hormone production and circulation, and affecting pregnancy outcomes [ 32 , 33 ]. This exposure might lead to periods of sterility, substantially increasing the risks of miscarriage and stillbirth if pregnancy does occur.…”

Section: Discussionmentioning

confidence: 99%

“…To recognize these alterations, pathologists must have knowledge of the continuously changing histological appearance of the various components of the reproductive tract during the cycle and must accurately and consistently ascribe individual tracts. Although comprehensive reports illustrating the normal appearance of the tract during the rat estrous cycle have been available for many years, these changes can be difficult to discern [ 32 , 37 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that lead exposure can adversely affect the reproductive system of both males and females [ 31 , 32 , 33 , 34 , 48 , 49 ]. In males, blood lead levels exceeding 40 μg/dL can cause a reduction in sperm count and changes in sperm volume, motility, and morphology [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

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Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

Osowski,

Fedoniuk,

Bilyk

et al. 2023

Toxics

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Lead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group, a low-dose group, a moderate-dose group, and a high-dose group. The rats were given lead acetate solutions in varying doses for 30 days, and their ovarian tissue was examined using light microscopy.The results showed that increasing doses of lead acetate led to morphological changes in the cortex and medulla of the rat ovaries. The changes were characterized by a decrease in ovarian mass, alterations in the thickness of the tunica albuginea (protein envelope), and a reduction in the number of follicles. Light microscopy revealed that exposure to lead acetate resulted in a significant decrease in the number of follicles in all experimental groups, with the high-dose group experiencing the most significant decrease.These findings suggest that lead acetate has a dose-dependent negative impact on the morphology and function of female rat ovaries. Further studies are needed to investigate the potential impact of lead on human ovarian tissue.

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