Methodological contributions towards LC–MS/MS quantification of free VX in plasma: An innovative approach

Debouit, Charlotte; Bazire, A.; Lallement, G.; Daveloose, Denis

doi:10.1016/j.jchromb.2010.08.050

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Similar research was done in 2010 by H. John for sarin, soman, tabun, cyclosarin, VX, Chinese VX, Russian VX, chlorpyrifos-oxon, DFP, paraoxonethyl, and profenofos . LC-MS/MS was also used as detection technique for VX in blood plasma and microdialysates. , Chiral quantification of tabun enantiomers in swine blood was carried out by O. Tenberken by GC-PCI-MS . Developed GC-MS can allow for the detection of nerve agents at an exposure level of 1% BuChE inhibition, where ChE activity assay cannot be verified …”

Section: Sensing and Detectionmentioning

confidence: 95%

Destruction and Detection of Chemical Warfare Agents

et al. 2011

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Section: Sensing and Detectionmentioning

confidence: 95%

Destruction and Detection of Chemical Warfare Agents

et al. 2011

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“…EA-2192 recovery rate (69%, average value for three concentrations) was slightly below the recovery rate of VX (74%). Quantification data of EA-2192 in biological matrices are not available in the open literature while VX recovery rates of 65% (human plasma [47]), 75% (swine hemolysed blood [2]) and 80-90% (one step direct extraction from guinea pig blood [48]) were published.…”

Section: Recoveriesmentioning

confidence: 99%

Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies

Reiter

Mikler

Hill

et al. 2011

Journal of Chromatography B

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“…LC/MS/MS and LC/ICP/MS have been used to detect G-agents, V-agents and their degradation products. 17 While these techniques (and others) are still in the development/optimization stage, hydrolysis products have been detected near 1 ppb.…”

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confidence: 99%

Lewis acid-assisted detection of nerve agents in water

et al. 2015

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The five-coordinate compound, Salen((t)Bu)Al(Ac), prepared in situ from Salen((t)Bu)AlBr and NH4Ac, forms Lewis acid-base adducts in aqueous solution with the G-type nerve agents, Sarin and Soman, and the VX hydrolysis product, ethylmethylphosphonate (EMPA). The resulting compounds, [Salen((t)Bu)Al(NA)](+)[Ac] (-) (with NA = Sarin, Soman, and EMPA) are sufficiently stable to be identified by ESI-MS. Molecular ion peaks were detected for every compound with little or no fragmentation. The distinctive MS signatures for the [Salen((t)Bu)Al(NA)](+) compounds provide a new technique for identifying nerve agents from aqueous solution. The energetics of the displacement of Ac(-) by the nerve agents to form [Salen((t)Bu)Al(NA)](+)[Ac](-) were determined computationally.

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Methodological contributions towards LC–MS/MS quantification of free VX in plasma: An innovative approach

Cited by 9 publications

References 19 publications

Destruction and Detection of Chemical Warfare Agents

Destruction and Detection of Chemical Warfare Agents

Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies

Lewis acid-assisted detection of nerve agents in water

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