Methodological Issues in Epidemiological, Prevention, and Treatment Research on Drug-Exposed Women and Their Children

Kilbey, M. Marlyne; Asghar, Khursheed

doi:10.1037/e496172006-001

Cited by 9 publications

(7 citation statements)

References 202 publications

(260 reference statements)

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“…17 However, it is difficult to recruit and retain heavy drinkers in longitudinal studies, particularly mothers with a diagnosed alcohol-use disorder, as they have complex family problems and frequent family moves. 18,19 Studies using routinely collected linked population-based data overcome these limitations and enable the examination of pregnancy outcomes of high-risk mothers with an alcoholrelated diagnosis, which is a proxy for alcohol-use disorder.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes of mothers with an alcohol‐related diagnosis: a population‐based cohort study for the period 1983–2007

Srikartika

O’Leary

2014

BJOG

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Objective To examine fetal outcomes of mothers with an alcoholrelated diagnosis.Design Population-based cohort. Setting Western Australia (WA).Population Births on the WA Midwives Notification System .Methods Infants of mothers with an alcohol-related diagnosis [International Classification of Disease (ICD), 9th/10th revisions] recorded on WA health data sets (non-Aboriginal n = 13 807; Aboriginal n = 9766) were identified through the WA data linkage system. A comparison cohort of infants born to mothers without an alcohol diagnosis was frequency matched on maternal age, year of birth of the offspring, and Aboriginal status (non-Aboriginal n = 40 148; Aboriginal n = 20 643).Main outcome measures Poisson regression-generated adjusted relative risk (aRR) and 95% confidence intervals (95% CIs) for small for gestational age (SGA), preterm birth, and low-Apgar score, calculated separately for non-Aboriginal and Aboriginal infants of mothers with an alcohol diagnosis recorded during pregnancy and any alcohol diagnosis. Population-attributable fractions were calculated.Results The aRR for non-Aboriginal infants when a maternal alcohol diagnosis was recorded during pregnancy ranged from 1.79 (95% CI 1.42-2.16) for SGA to 2.57 (95% CI 1.69-4.27) for preterm birth <32 weeks of gestation, and for Aboriginal infants ranged from 2.69 (95% CI 2.28-3.16) to 1.99 (95% CI 1.40-2.84), respectively. The highest population-atributable fractions were for any alcohol diagnosis and for Aboriginal infants. For Aboriginal births, approximately 9% (95% CI 4.74-12.97) and 10.1% (95% CI 5.50-14.49) of moderate and very preterm births, respectively, and 24.4% (95% CI 13.5-21.2%) of SGAs were attributable to having a mother with any alcohol-related diagnosis.Conclusions Mothers with an alcohol diagnosis are at increased risk of poor pregnancy outcomes. The public health impact of maternal alcohol-use disorders on fetal outcomes is significant.

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Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes of mothers with an alcohol‐related diagnosis: a population‐based cohort study for the period 1983–2007

Srikartika

O’Leary

2014

BJOG

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“…2 As many as 200,000 individuals (3.5%) of the population of that city are estimated to be HIV positive. This means that, for every symptomatic individual, [20][21][22][23][24][25][26][27][28][29][30] individuals have no symptoms at alJ and are, for the most part, unaware of their infection. Fewer than 5% of those infected can be expected to develop AIDS within 5 years, and the mean interval is more than 10 years.…”

Section: Epidemiologymentioning

confidence: 99%

“…2 Both the absolute numbers and the percentage of women with HIV infection are increasing. Among women with symptomatic AIDS, 61% of the cumulative cases are the result of their own drug use, while 23 % of cases are assigned to drug-using sexual partners. 2 AIDS is the leading cause of death in women between ages 15 and 44 years in New York and the fifth leading cause of death of all American women in the reproductive-age group.…”

Section: Epidemiologymentioning

confidence: 99%

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Human Immunodeficiency Virus Infection and Pregnancy

Minkoff

2014

Sexually Transmitted Diseases and Adverse Outcomes of Pregnancy

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The human immunodeficiency virus (HIV) epidemic is clearly one of the most serious health-care crises in the professional lives of contemporary physicians. It cannot be regarded as a curiosity to be dealt with by inner-city infectious-disease experts, but rather must be considered a problem for all health-care providers and a problem in which the obstetrician-gynecologist has a special role to play. (C) 1994 Wiley-Liss, Inc. KEY WORDS AIDS, perinatal transmission, AZT, pneumocystis as the human immunodeficiency virus (HIV) epidemic really abated? There is evidence of a leveling off of new cases in the gay male population generally, although a recent resurgence has been reported among young gay males in San Francisco.

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“…Precedence was set for a cooperative examination of a variety of challenging issues asserted to be inherent in this area of research. In July 1990 a technical review was held on methodological issues in epidemiological, prevention, and treatment research on drug-exposed women and their children that resulted in the publication of a NIDA research monograph (Kilbey and Asghar 1992). Several Perinatal-20 researchers contributed to this earlier volume because they had already encountered some of the difficulties associated with conducting research in this area.…”

Section: Researchmentioning

confidence: 99%

Introduction to the Perinatal-20 Treatment Research Demonstration Program

1996

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Methodological Issues in Epidemiological, Prevention, and Treatment Research on Drug-Exposed Women and Their Children

Cited by 9 publications

References 202 publications

Pregnancy outcomes of mothers with an alcohol‐related diagnosis: a population‐based cohort study for the period 1983–2007

Pregnancy outcomes of mothers with an alcohol‐related diagnosis: a population‐based cohort study for the period 1983–2007

Human Immunodeficiency Virus Infection and Pregnancy

Introduction to the Perinatal-20 Treatment Research Demonstration Program

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