2024
DOI: 10.3233/jnd-230217
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Methodological Quality of Clinical Trials in Amyotrophic Lateral Sclerosis: A Systematic Review

Elisabetta Pupillo,
Ammar Al-Chalabi,
Serena Sassi
et al.

Abstract: Background: More than 200 clinical trials have been performed worldwide in ALS so far, but no agents with substantial efficacy on disease progression have been found. Objective: To describe the methodological quality of all clinical trials performed in ALS and published before December 31, 2022. Methods: We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta Analyses. Results: 213 trials were included. 47.4% manuscripts described preclinical study evaluation, w… Show more

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