Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A <scp>TASK</scp>1‐<scp>WG</scp>3 report of the <scp>AES</scp>/<scp>ILAE</scp> Translational Task Force of the ILAE

Hernan, Amanda E.; Schevon, Catherine A.; Worrell, Gregory A.; Galanopoulou, Aristea S.; Kahane, Philippe; Curtis, Marco de; Ikeda, Akio; Quilichini, Pascale; Williamson, Adam; García-Cairasco, Norberto; Scott, Rod C.; Timofeev, Igor

doi:10.1111/epi.13905

Cited by 13 publications

(20 citation statements)

References 33 publications

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“…Flexible multielectrode arrays can also be used for recording epidurally from the brain's surface . Depth electrodes will be the focus of a different article in this Supplement …”

Section: Methodological Considerationsmentioning

confidence: 99%

“…18 Depth electrodes will be the focus of a different article in this Supplement. 19 The limitations of skull-attached recordings in rodents include the short interelectrode distances due to anatomical spatial constraints and the volume conduction (see Data S1). 20 Selection of electrode derivations that are farther apart can aid in the identification of the source localization of particular EEG rhythms/seizure initiation zones.…”

Section: Types Of Eeg Recordings and Electrodesmentioning

confidence: 99%

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Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

Kadam

D’Ambrosio

Duveau³

et al. 2017

Epilepsia

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SUMMARY In vivo electrophysiological recordings are widely used in neuroscience research and video-electroencephalography (vEEG) has become a mainstay of preclinical neuroscience research, including studies of epilepsy and cognition. Studies utilizing vEEG typically involve comparison of measurements obtained from different experimental groups, or from the same experimental group at different times, in which one set of measurements serves as “control”, and the others as “test” of the variables of interest. Thus, controls provide mainly a reference measurement for the experimental test. Control rodents represent an undiagnosed population, and cannot be assumed to be “normal” in the sense of being “healthy.” Certain physiological EEG patterns seen in humans are also seen in control rodents. However, interpretation of rodent vEEG studies relies on documented differences in frequency, morphology, type, location, behavioral state dependence, reactivity and functional or structural correlates of specific EEG patterns and features between control and test groups. This paper will focus on the vEEG of standard laboratory rodent strains with the aim of developing a small set of practical guidelines that can assist researchers in the design, reporting, and interpretation of future vEEG studies. To this end, we will: 1) discuss advantages and pitfalls of common vEEG techniques in rodents and propose a set of recommended practices and 2) present EEG patterns and associated behaviors recorded from adult rats of a variety of strains. We will describe the defining features of selected vEEG patterns (brain-generated or artifactual) and note similarities to vEEG patterns seen in adult humans. We will note similarities to normal variants or pathological human EEG patterns and defer their interpretation to a future report focusing on rodent seizure patterns.

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“…Flexible multielectrode arrays can also be used for recording epidurally from the brain's surface . Depth electrodes will be the focus of a different article in this Supplement …”

Section: Methodological Considerationsmentioning

confidence: 99%

Section: Types Of Eeg Recordings and Electrodesmentioning

confidence: 99%

Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

Kadam

D’Ambrosio

Duveau³

et al. 2017

Epilepsia

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“…This manuscript of the ILAE/AES Joint Translational TF introduces the preclinical CDEs organized into case report forms (CRFs) for preclinical studies utilizing electroencephalography (EEG), video‐EEG (vEEG), or electrophysiologic recordings in rodents. The recently published reports of the TASK1 groups of ILAE/AES Joint Translational TF outline some of the methodologic and reporting practices for the acquisition, interpretation, and analysis, including software‐based, of EEG performed in experimental control rodents . In addition, readers may refer to additional considerations on reporting experimental methods and welfare of animals used for epilepsy research reported by Lidster et al.…”

mentioning

confidence: 99%

“…The recently published reports of the TASK1 groups of ILAE/AES Joint Translational TF outline some of the methodologic and reporting practices for the acquisition, interpretation, and analysis, including software-based, of EEG performed in experimental control rodents. [9][10][11][12] In addition, readers may refer to additional considerations on reporting experimental methods and welfare of animals used for epilepsy research reported by Lidster et al (2016). 13 Here, we discuss how some of these principles can be incorporated in CDE and CRF documents to help guide the reader about which data and metadata would be helpful to be reported and catalogued in such forms.…”

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confidence: 99%

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force

et al. 2018

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SummaryElectroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix S1).

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“…The TASK1‐WG1 group reports on best practices pertaining to studies using surface or epi‐/subdural EEG in adult rodent controls . The TASK1‐WG3 group addresses the methodologies and interpretation of depth electrophysiologic in studies in vivo in adult rodent controls, whereas the TASK1‐WG4 group focuses on in vitro electrophysiologic studies . The TASK1‐WG5 group proposes standards for data acquisition and analysis for the electrophysiologic recordings .…”

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confidence: 99%

Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiative

et al. 2017

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Among the priority next steps outlined during the first translational epilepsy research workshop in London, UK (2012), jointly organized by the American Epilepsy Society (AES) and the International League Against Epilepsy (ILAE), are the harmonization of research practices used in preclinical studies and the development of infrastructure that facilitates multicenter preclinical studies. The AES/ILAE Translational Task Force of the ILAE has been pursuing initiatives that advance these goals. In this supplement, we present the first reports of the working groups of the Task Force that aim to improve practices of performing rodent video EEG studies in experimental controls, generate systematic reviews of preclinical research data, and develop preclinical common data elements (CDEs) for epilepsy research in animals.

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Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1‐WG3 report of the AES/ILAE Translational Task Force of the ILAE

Abstract: Summary This paper is a result of work of Translational Task Force of the ILAE Neurobiology Commission. The aim is to provide acceptable standards and interpretation of results of electrophysiological recordings in vivo in control rodents.

Cited by 13 publications

References 33 publications

Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

Methodological standards and interpretation of video‐electroencephalography in adult control rodents. A TASK1‐WG1 report of theAES/ILAETranslational Task Force of the ILAE

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force

Harmonization in preclinical epilepsy research: A joint AES/ILAE translational initiative

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