Creative industries, by their nature of innovation through creativity, add value to any territory by giving it spatial functionality, and at the same time, they favour sustainable development through the sustainability of the urban centres in which they operate. This paper develops a GIS methodology based on the implementation of a spatial analysis model that captures, in a comparative way, the spatial functionality of two different urban centres—(Cluj-Napoca (Romania) and Pécs (Hungary))—in terms of spatial extent based on the impact of the spatial distribution of creative industries. The spatial analysis model is based on the management of alpha-numeric databases representing the addresses of the creative industries, based on geolocation, for the development of spatial analyses of pedestrian accessibility. The main aim is to identify the specific areas of 15 and 5 min model cities. The comparative analysis was carried out by implementing a deterministic methodology through which the areas with certain degrees of accessibility were analysed in relation to the total analysed area, with the main aim of standardising the scale of analysis due to the difference between the two urban centres, thus facilitating the use of qualitative boning in the final comparison process. The results obtained highlight the local behaviour, at the same time making it possible to conduct a realistic deterministic comparative analysis of the two urban centres, which are also identifiable from the point of view of local territorial functionality, thereby validating the GIS model implemented in the present study.