(1) Background: The present development of transport networks focusses on the better management of fuels and energy and the preservation of the environment. To fulfill these desiderates, some countries have already reconsidered the deployment plans of new highways. This research studies the feasibility of less polluting, quasi-self-powered, intelligent highway infrastructure functional blocks accommodating functions for the future introduction of smart wireless sensor grids and connected autonomous vehicles. Subject of investigation are the possibilities of energy harvesting, and the intelligent management of resources. (2) Methods: the research investigates the main technologies for energy harvesting and recommends an optimal solution. It also proposes a framework for the intelligent, AI-based management of energy and the use of an optimized backup solution relying on 5G beamforming for energy supply of the local wireless sensing network devices; (3) Results: recommendations are made for the best energy harvesting solution, an architecture of the energy management system, an algorithm for energy management and backup solution based on 5G beamforming; (4) Conclusions: the research emphasizes the advantages and drawbacks for different solutions regarding energy harvesting in an intelligent green highway scenario with a focus on the infrastructure developed to accommodate future connected and autonomous vehicles. The term “intelligent highway” must be understood in the automotive industry to describe a network of roads where cars communicate with the infrastructure and among themselves for the purpose of avoiding congestion and performing the seamless operation of services, and a space where cars and infrastructure cooperatively process information for obtaining better road safety, less pollution, and efficient energy management. With the recent recession of conventional fuel availability and the increase in prices, a solution to improving autonomy of both cars and infrastructure might be welcomed.