The paper discusses the problems connected with long-term exploitation of reinforced concrete post-tensioned girders. The scale of problems in the world related to the number of cable post-tensioned concrete girders built in the 1950s and still in operation is very large and possibly has very serious consequences. The paper presents an analysis and evaluation of the results of measurements of the deflection and strength and homogeneity of concrete in cable–concrete roof girders of selected industrial halls located in Poland, exploited for over 50 years. On the basis of the results of displacement monitoring in the years 2009–2020, the maximum increments of deflection of the analyzed girders were determined. Non-destructive, destructive, and indirect evaluation methods were used to determine the compressive strength of concrete. Within the framework of the indirect method recommended in standard PN-EN 13791, a procedure was proposed by the authors to modify the so-called base curve for determining compressive strength. Due to the age of the analyzed structural elements, a correction factor for the age of concrete was taken into account in the strength assessment. The typical value of the characteristic compressive strength is within the range 20.3–28.4 MPa. As a result of the conducted tests, the concrete class assumed in the design was not confirmed, and its classification depended on the applied test method. The analyzed girders, in spite of their long-term exploitation, can be still used for years on the condition that regular periodical inspections of their technical condition are carried out. The authors emphasize the necessity for a permanent and cyclic diagnostic process and monitoring of the geometry of girders, as they are expected to operate much longer than was assumed by their designers.