“…manoeuvres which are (3) either nonexistent in his life style or blocked by external or internal restraints, there (4) ensues a state of perpetuating emotional arousal which, when not relieved, (5) causes an inappropriate activation of the autonomic nervous system and/or endocrine glands, leading to an acute psychophysiological manifestation in a vulnerable organ. In other words, we do not regard the turning-on point and mechanism as depending exclusively either on the patient's personality (Dunbar, 1943 ;Hollman & Hantel, 1949; Lang, 1950; Ruesch, 1948), or on the concepts of hopelessness (Engel, 1962; Greene, 1954), loss (Schmale, 1958), stress (Mitscherlich, 1961) or nonspecific stress adaptation (Wolff, 1953). Rather, this point results from the dynamic interaction of several sets in multiple systems, all coinciding to escalate the patient's emotional arousal.…”