To predict the chamber pressure of positions corresponding to the strain data of the gun barrelโ outside walls, this study measures the chamber pressure and strain of different positions in a recoilless gun, and proposes a chamber pressure calculation method which is based on strain measurement of cylinder walls using the single-layer thin-walled cylinder theory and the plane strain-elastic stress solution for multi-layer orthotropic cylinders. Experimental results showed that the deformation of the recoilless gun at different positions was caused by varying factors. Specifically, chamber deformation was attributed to the expansion of high-pressure propellant gas, showing a strain curve similar to that of chamber pressure. The deformation of the barrel part between the chamber throat and the muzzle was first caused by band engraving and then by the expansion of high-pressure propellant gas. If the effect of band engraving was neglected, the changes of chamber pressure there were found to be well in line with the chamber deformation caused by propellant gas expansion. The calculation results revealed that the relative errors between the chamber pressure values predicted by the proposed method and the measured ones were in the range of 0.82%-7.88%, suggesting that the proposed method can effectively predict chamber pressure. The calculation error at the chamber position was large, reaching 7.88%, due to the neglect of the gap between the cartridge case and the chamberโs inside walls. The pressure in the barrel part between the chamber throat and the muzzle was satisfactorily predicted, with a minimum error of 0.82% and a maximum error of only 5.89% at the muzzle.