Methods for endometrial preparation in frozen-thawed embryo transfer cycles

Kalem, Ziya; Kalem, Müberra Namlı; Gürgan, Timur

doi:10.5152/jtgga.2016.15214

Cited by 19 publications

(12 citation statements)

References 53 publications

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“…For a successful implantation, a receptive endometrium and synchronization between the endometrium and the embryo are essential 6. To date, several methods of endometrial preparation have been attempted 7. Spontaneous ovulation is monitored in natural cycles.…”

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confidence: 99%

Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer

Kalem

Bakırarar

et al. 2018

SMJ

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Objectives:To compare implantation rates, clinical pregnancy rates and live birth rates associated with natural and hormone replacement therapy (HRT) methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles.Methods:The results of 108 natural cycles and 224 HRT cycles of FET transfers performed in a private in vitro fertilization (IVF) center between June 2013 and August 2015 were retrospectively compared with respect to implantation rate, clinical pregnancy rate, and live birth rate.Results:A total of 144 embryos were transferred in 108 natural cycles and 357 embryos were transferred in 224 HRT cycles. No statistically significant differences were found in the implantation rate (p=0.796), clinical pregnancy rate per cycle (p=0.900), clinical pregnancy rate per transferred embryo (p=0.283), live birth rate per cycle (p=0.821), or live birth rate per transferred embryo (p=0.481) between the 2 groups.Conclusion:This study showed no difference between the implantation rate, clinical pregnancy rate or live birth rate between the natural cycle group and HRT cycle group. These results may provide clinicians with more freedom to individualize patient treatment, particularly with respect to the selection of the endometrial preparation method, if these results are supported by large randomized controlled studies in the future.

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confidence: 99%

Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer

Kalem

Bakırarar

et al. 2018

SMJ

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“…One possible reason why RA‐RI in the early follicle phase was not predictive of pregnancy outcomes during the HRT cycle may be the effect of exogenously administered estrogen. The serum estradiol concentration averages around 100 pg/mL during the early to late follicular phase of the normal menstrual cycle, 48 whereas that exceeds 200 pg/mL with transdermal administration of estradiol during the HRT cycle 49,50 . In other words, an increase in endometrial blood flow would be expected due to higher estradiol levels in the HRT cycle than in the natural cycle.…”

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confidence: 99%

Relationship between temporal changes of endometrial blood flow impedance during natural and hormone replacement cycles and prediction of pregnancy during vitrified‐warmed embryo transfer

Ota

Shiraishi

Takahashi

2021

J of Obstet and Gynaecol

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Aim This study aimed to examine the relationship between the temporal changes in endometrial blood flow impedance during natural and hormone replacement therapy (HRT) cycles and clinical outcomes of vitrified‐warmed embryo transfer (ET). Methods This retrospective observational cohort study included 60 women, 28 with natural, and 32 with HRT cycles, who underwent vitrified‐warmed ET. Uterine radial artery resistance index (RA‐RI) was measured during the natural and HRT cycles at the following time points: early follicular phase, day of the human chorionic gonadotropin injection during a natural cycle or day of progesterone administration during an HRT cycle, and day of ET. Results The clinical pregnancy rates of the natural and HRT cycles were 32.1% and 34.4%, respectively. The RA‐RI at the early follicular phase was significantly lower in the pregnant group than in the nonpregnant group with natural but not HRT cycles (p = 0.04). The odds ratio for pregnancy was 0.70 (95% confidence interval [CI], 0.52–0.95) when the RA‐RI value at the early follicular phase was increased by 0.01 in the natural cycle. With the natural cycle, the area under the receiver‐operating characteristic curves for the RA‐RI at the early follicular phase with a threshold of 0.68 was 0.75 (95% CI, 0.57–0.93), and the positive and negative predictive values were 0.53 (95% CI, 0.37–0.59) and 0.92 (0.74–0.99), respectively. Conclusion RA‐RI at the early follicular phase might be an effective and useful tool for deciding between natural or HRT cycles for vitrified‐warmed ET.

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“…Some studies used different forms of GNRH-a and found no significant difference on the cycle outcome [23,18] . Kalem, et al [24] concluded that early luteinization may exist in 5% and complete down regulation with GNRH-a cannot be guaranteed in artificial cycles .The only detected positive factor affecting the pregnancy rate was the endometrial thickness which was determined by estrogen [25,26,27] .…”

Section: Discussionmentioning

confidence: 99%

Is addition of GNRH agonist to HRT significant in improving the outcome in FTE transfer cycles? Randomized study.

Salama

Souidan

2020

Evidence Based Women's Health Journal

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Background: Despite the high number of frozen embryo transfer cycles being conducted, there is much debate about which protocol for endometrial preparation is ideal. Aim: The aim of this study is detect the value of gonadotropin-releasing hormone agonist (GNRH-a) in the preparation of the endometrium regarding the cycle outcome. Materials and Methods: One hundred forty women participated in the study. They were randomly divided into two groups; group 1 and group 2. The patients of group 1 received injection of GnRH-a triptoreline (3.75 mg) on the day-21 of the menstrual cycle proceeding the replacement cycle. Both groups received exogenous estradiol starting from the second day of the cycle then the dose was increased incrementally till the endometrial thickness was ≥ 8mm or more. Progesterone was given to the patients before embryo transfer and continued thereafter. Twelve days later, serum pregnancy test was done and if positive, transvaginal ultrasonography was done two weeks later for detection of embryo cardiac activity. Results: Both groups showed no statistically significant differences regarding demographic, clinical and laboratory data and their relations to pregnancy. Serum pregnancy tests detected chemical pregnancy that was confirmed by transvaginal ultrasonography at 6 weeks gestation in only 49.3% of women (clinical pregnancy rate =49.3%). Only six women aborted at 8-12 weeks gestation (ongoing pregnancy rate =45%). There were no significant differences between both groups regarding the clinical outcome. Conclusion: Addition of GNRH-a to HRT to prepare the endometrium in the FTE transfer cycle had no significant effect on the clinical outcome.

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Methods for endometrial preparation in frozen-thawed embryo transfer cycles

Cited by 19 publications

References 53 publications

Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer

Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer

Relationship between temporal changes of endometrial blood flow impedance during natural and hormone replacement cycles and prediction of pregnancy during vitrified‐warmed embryo transfer

Is addition of GNRH agonist to HRT significant in improving the outcome in FTE transfer cycles? Randomized study.

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