Methods for Evaluating Endothelial Function in Humans

Barac, Ana; Campia, Umberto; Panza, Julio A.

doi:10.1161/01.hyp.0000259601.38807.a6

Cited by 123 publications

(94 citation statements)

References 134 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, baseline levels of PAI-1 correlated positively with the systolic blood pressure. PAI-1 is an inhibitor of fibrinolysis and a possible marker of endothelial dysfunction 46 that is associated with increased cardiovascular risk, especially the risk of myocardial infarction in the presence of insulin resistance, 47 and belongs to the non-standard features of the metabolic syndrome. Recently, several studies reported that incretin mimetics had wide range of additional protective effects on the cardiovascular system.…”

mentioning

confidence: 99%

Insulin resistance in young, lean male subjects with essential hypertension

Penesová

Cizmárová²,

Белан

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

Impaired insulin action, frequently found in essential hypertension (HT), is modified by other factors, such as higher age, accumulation of body fat, dyslipidaemia, impaired glucose metabolism and endothelial dysfunction. In addition, antihypertensive and insulin-sensitizing medication itself may significantly affect cardiovascular and metabolic milieu. The aim of this study was to assess insulin sensitivity, acute insulin response, lipidaemic status and the adipokines' concentrations with regard to abdominal fat distribution in young, lean male subjects with treatment-naïve essential HT and in matched healthy normotensive (NT) subjects. We studied 27 HT patients (age: 19.9 ± 0.6 years; body mass index (BMI): 22.9±0.5 kg m À2) and 15 NT controls (age: 22.3±1.0 years; BMI: 23.7 ± 0.6 kg m À2). The subjects underwent an oral and an intravenous glucose tolerance test (OGTT, IVGTT) on separate days in random order. Higher fasting insulin (Po0.001), non-esterified fatty acids (Po0.05) and plasminogen activator inhibitor factor 1 concentrations (Po0.05) were found in HT patients when compared with NT patients. Despite comparable anthropometric parameters and body fat distribution assessed by magnetic resonance imaging in both groups, newly diagnosed untreated young hypertensive male subjects showed decreased insulin sensitivity, augmented insulin response to both oral and intravenous glucose load (Po0.01; Po0.05 respectively) and 'higher still normal' 2-h plasma glucose levels during OGTT. Untreated, young, lean hypertensive male subjects, with distribution of abdominal adipose tissue and lipid profile comparable with their healthy NT matched counterparts, showed considerable signs of insulin resistance and hyperinsulinaemia. We hypothesize that insulin resistance is the initial feature, which is influenced by several environmental factors, and HT is one of their common consequences.

show abstract

mentioning

confidence: 99%

Insulin resistance in young, lean male subjects with essential hypertension

Penesová

Cizmárová²,

Белан

et al. 2010

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…Several novel techniques have been devised to explore different facets of endothelial function in vivo 19) , including endothelial expression of inflammatory markers, adhesive properties of the endothelium with respect to interactions with leukocytes and platelets, and factors involved in the regulation of thrombosis and fibrinolysis, as well as endothelial progenitor cells. Although these are particularly useful in large scale, prospective studies in which peripheral blood samples can be used, these factors currently have only a very limited role in the assessment of individual patients because of biological and assay availability and variability 5) .…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, measurements of the endothelial function of coronary artery circulation by angiography and of forearm circulation by plethysmography, have been well studied thus far, but their clinical use is limited due to being invasive procedures 20) . Recently, a technique for assessing endothelial function by non-invasive FMD measurement of the brachial artery using high-resolution ultrasonography has been developed, and widely used 19) . Measurement of FMD can evaluate the effects of cardiovascular risk factors on conductance vessels, the site of atherosclerotic plaque formation.…”

Section: Discussionmentioning

confidence: 99%

Advanced Endothelial Dysfunction in Diabetic Patients with Multiple Risk Factors; Importance of Insulin Resistance

Tsuchiya

Nakayama

Iwashima

et al. 2007

JAT

View full text Add to dashboard Cite

Aim: Endothelial dysfunction is considered an early event in the development of atherosclerosis. The present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients. Methods: 101 patients with type 2 diabetes without macroangiopathy stratified by the number of cardiovascular risk factors (dyslipidemia, hypertension, obesity) and 9 normal control subjects were studied for vascular endothelial functions by measuring flow-mediated vasodilation (FMD) using a high-resolution ultrasound method, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT), and the ankle-brachial index (ABI).

show abstract

“…Utilizing validated techniques, endothelium-dependent endothelial function was assessed using a brachial artery flow-mediated vasodilation technique. [22][23][24] Following a 10-minute period of rest, endothelium-independent function was assessed at the identical arterial location, following response to sublingual glyceryl trinitrate, 24 and images analyzed offline.…”

Section: Brachial Artery Flow-mediated Dilatationmentioning

confidence: 99%

The deleterious effects of arteriovenous fistula-creation on the cardiovascular system: a longitudinal magnetic resonance imaging study

Dundon¹,

Torpey²,

Nelson³

et al. 2014

IJNRD

View full text Add to dashboard Cite

Aim: Arteriovenous fistula-formation remains critical for the provision of hemodialysis in endstage renal failure patients. Its creation results in a significant increase in cardiac output, with resultant alterations in cardiac stroke volume, systemic blood flow, and vascular resistance. The impact of fistula-formation on cardiac and vascular structure and function has not yet been evaluated via "gold standard" imaging techniques in the modern era of end-stage renal failure care. Methods: A total of 24 patients with stage 5 chronic kidney disease undergoing fistula-creation were studied in a single-arm pilot study. Cardiovascular magnetic resonance imaging was undertaken at baseline, and prior to and 6 months following fistula-creation. This gold standard imaging modality was used to evaluate, via standard brachial flow-mediated techniques, cardiac structure and function, aortic distensibility, and endothelial function. , and left ventricular mass were observed (12.7% increase) (P,0.01). Endothelial-dependent vasodilation was significantly decreased at follow up (9.0%±9% vs 3.0%±6%) (P=0.01). No significant change in aortic distensibility was identified. Conclusion:In patients with end-stage renal failure, fistula-formation is associated with an increase in cardiac output, dilation of all cardiac chambers and deterioration in endothelial function.

show abstract

Methods for Evaluating Endothelial Function in Humans

Cited by 123 publications

References 134 publications

Insulin resistance in young, lean male subjects with essential hypertension

Insulin resistance in young, lean male subjects with essential hypertension

Advanced Endothelial Dysfunction in Diabetic Patients with Multiple Risk Factors; Importance of Insulin Resistance

The deleterious effects of arteriovenous fistula-creation on the cardiovascular system: a longitudinal magnetic resonance imaging study

Contact Info

Product

Resources

About