Methods for evaluating the puncture and shear properties of pharmaceutical polymeric films

Radebaugh, Galen W.; Murtha, John L.; Julian, Thomas N.; Bondi, Joseph N.

doi:10.1016/0378-5173(88)90032-4

Cited by 66 publications

(31 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a result, the development of XG films was discontinued. CMC and SA have already been identified as good film formers 41 and were easier to handle than XG.…”

Section: Discussionmentioning

confidence: 99%

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Boateng

Stevens

Eccleston

et al. 2009

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to determine the most effective means of preparing gels for each of the three polymers. Different drying conditions [relative humidity - RH (6-52%) and temperature (3-45 degrees C)] were investigated to determine the effect of drying rate on the films prepared by drying the polymeric gels. The tensile properties of the CMC films were determined by stretching dumbbell-shaped films to breaking point, using a Texture Analyser. Glycerol was used as a plasticizer, and its effects on the drying rate, physical appearance, and tensile properties of the resulting films were investigated. Vortex hydration with heating was the method of choice for preparing gels of SA and CMC, and cold hydration for xanthan gels. Drying rates increased with low glycerol content, high temperature, and low relative humidity. The residual water content of the films increased with increasing glycerol content and high relative humidity and decreased at higher temperatures. Generally, temperature affected the drying rate to a greater extent than relative humidity. Glycerol significantly affected the toughness (increased) and rigidity (decreased) of CMC films. CMC films prepared at 45 degrees C and 6% RH produced suitable films at the fastest rate while films containing equal quantities of glycerol and CMC possessed an ideal balance between flexibility and rigidity.

show abstract

“…As a result, the development of XG films was discontinued. CMC and SA have already been identified as good film formers 41 and were easier to handle than XG.…”

Section: Discussionmentioning

confidence: 99%

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Boateng

Stevens

Eccleston

et al. 2009

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

“…Hence, they should have the required resistance to damage caused by compression. Radebaugh et al (69) has reported a new device that can determine the process of puncture on polymeric films directly. It measures the resistance of a film sample, which is mounted on a fixed holder, to deformation with a puncturing probe attached to a force transducer.…”

Section: Puncture Testmentioning

confidence: 99%

Novel Film Modifiers to Alter the Physical Properties of Composite Ethylcellulose Films

2005

View full text Add to dashboard Cite

show abstract

“…Exponent software (Stable Microsystems, Godalming, Surrey, UK) was used to process data. Tensile strength was calculated as shown in Equation 6, as defined by Radebaugh et al (Radebaugh et al, 1988). 220 11 where F is the force at rupture (N) and A cs is the cross sectional area of the film in the film holder (mm 2 ).…”

Section: Mechanical Strength Testingmentioning

confidence: 99%

Influence of process parameters on the preparation of pharmaceutical films by electrostatic powder deposition

Prasad

LaFountaine

Keen

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Electrostatic powder deposition (ESPD) has been developed as a solvent-free method to prepare pharmaceutical films. The aim of this work was to investigate the influence of process parameters during (1) electrostatic powder deposition, (2) curing, and (3) removal of the film from the substrate on the properties of the film. Polyethylene oxide (PEO) was used as the model polymer and stainless steel 316 as the substrate. Deposition efficiency (i.e. deposited weight) was measured with varying charging voltage, gun tip to substrate distance, and environmental humidity. Scanning electron microscopy was utilized to assess film formation, and adhesive and mechanical strength of films were measured with varying cure temperature and time. Adhesive strength was measured for films prepared on substrates of varying surface roughness. When deposition was performed at low humidity conditions, 25%RH, process parameters did not significantly affect deposition behavior. At 40%RH, increasing deposition efficiency with decreasing gun tip to substrate distance and increasing voltage (up to 60kV) was observed. Complete film formation was seen by 30min at 80°C, compared to lower curing temperatures and times. All films were readily removed from the substrates. The results show the ESPD process can be modified to produce films with good mechanical properties (e.g. tensile strength>0.06MPa), suggesting it is a promising dry powder process for preparing pharmaceutical films.

show abstract

Methods for evaluating the puncture and shear properties of pharmaceutical polymeric films

Cited by 66 publications

References 3 publications

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces

Novel Film Modifiers to Alter the Physical Properties of Composite Ethylcellulose Films

Influence of process parameters on the preparation of pharmaceutical films by electrostatic powder deposition

Contact Info

Product

Resources

About