Methods for producing the Mn52 isotope

Dmitriev, P. P.; Константинов, И. О.; Krasnov, N. N.

doi:10.1007/bf01174115

Cited by 15 publications

(7 citation statements)

References 5 publications

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“…The standard models lead to a significant underestimation of the higher-energy data, as suggested also from the dash-dot line in figure 1. The available experimental data 30,31,32,33,34,35,36,37,38,39,40 reported in the figure were taken from the EXFOR database 41 .…”

Section: Iiia Cross Sectionsmentioning

confidence: 99%

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

Barbaro¹,

L.²,

Carante³

et al. 2022

Preprint

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Background: Manganese is a paramagnetic element suitable for magnetic resonance imaging (MRI) of neuronal function, however high concentrations of Mn 2+ can cause neurological disorders. 52g Mn appears a valid alternative as PET (positron emission tomography) imaging agent, to obtain information similar to that delivered by MRI but using trace levels of Mn 2+ , thus reducing its toxicity. Recently, the reaction nat V(α,x) 52g Mn has been proposed as a possible alternative to the standard nat Cr(p,x) 52g Mn one, but improvements in the modeling were needed to better compare the two production routes. Purpose: This work focuses on the development of precise simulations and models to compare the 52g Mn production from both reactions in terms of amount of activity and radionuclidic purity (RNP), as well as in terms of dose increase (DI) due to the co-produced radioactive contaminants, with respect to a pure 52g MnCl 2 injection. Methods: The nuclear code Talys has been employed to optimize the nat V(α,x) 52g Mn cross section by tuning the parameters of the microscopic level densities. Thick target yields have been calculated from the expression of the rates as energy convolution of cross sections and stopping powers, and finally integrating the time evolution of the relevant decay chains. Dosimetric assessments of [ xx Mn]Cl 2 have been accomplished with OLINDA software 2.2.0 using female and male phantoms. At the end, the yield of xx Mn radioisotopes estimated for the two production routes have been combined with the dosimetric results, to assess the DI at different times after the end of the irradiation. Results: Good agreement was obtained between cross sections calculations and measurements. The comparison of the two reaction channels suggests that nat V(α,x) 52g Mn leads to higher yield and higher purity, resulting in a less harmful impact on patients' health in terms of DI. Conclusions: Both nat V(α,x) and nat Cr(p,x) production routes provide clinically acceptable 52g MnCl 2 for PET imaging. However, the nat V(α,x) 52g Mn reaction provides a DI systematically lower than the one obtainable with nat Cr(p,x) 52g Mn and a longer time window in which it can be used clinically (RNP ≥ 99%).

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Section: Iiia Cross Sectionsmentioning

confidence: 99%

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

Barbaro¹,

L.²,

Carante³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The standard models lead to a considerable underestimation of the higher-energy data, as suggested also from the dash-dot line in Figure 1. The available experimental data [30][31][32][33][34][35][36][37][38][39][40] reported in the figure were taken from the EXFOR database. 41 Contaminant radioisotopes produced by this reaction route are characterized either by a very short, or by a very long, half -life.…”

Section: Cross Sectionsmentioning

confidence: 99%

The innovative ^52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation

et al. 2022

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Background: Manganese is a paramagnetic element suitable for magnetic resonance imaging (MRI) of neuronal function. However, high concentrations of Mn 2+ can be neurotoxic. 52g Mn may be a valid alternative as positron emission tomography (PET) imaging agent, to obtain information similar to that delivered by MRI but using trace levels of Mn 2+ , thus reducing its toxicity. Recently, the reaction nat V(𝛼,x) 52g Mn has been proposed as a possible alternative to the standard nat Cr(p,x) 52g Mn one, but improvements in the modeling were needed to better compare the two production routes. Purpose: This work focuses on the development of precise simulations and models to compare the 52g Mn production from both reactions in terms of amount of activity and radionuclidic purity (RNP), as well as in terms of dose increase (DI) due to the co-produced radioactive contaminants, versus pure 52g MnCl 2 . Methods: The nuclear code Talys has been employed to optimize the nat V(𝛼,x) 52g Mn cross section by tuning the parameters of the microscopic level densities. Thick-target yields have been calculated from the expression of the rates as energy convolution of cross sections and stopping powers, and finally integrating the time evolution of the relevant decay chains. Dosimetric assessments of [ xx Mn]Cl 2 have been accomplished with OLINDA software 2.2.0 using female and male adult phantoms and biodistribution data for 52g MnCl 2 in normal mice. At the end, the yield of xx Mn radioisotopes estimated for the two production routes have been combined with the dosimetric results, to assess the DI at different times after the end of the irradiation. Results: Good agreement was obtained between cross-section calculations and measurements. The comparison of the two reaction channels suggests that nat V(𝛼,x) 52g Mn leads to higher yield and higher purity,resulting in more favorable radiation dosimetry for patients. Conclusions: Both nat V(𝛼,x) and nat Cr(p,x) production routes provide clinically acceptable 52g MnCl 2 for PET imaging. However, the nat V(𝛼,x) 52g Mn reaction provides a DI systematically lower than the one obtainable with nat Cr(p,x) 52g Mn and a longer time window in which it can be used clinically (RNP ≥ 99%).

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“…In addition, the data by Dmitriev at al. [7] are reported together with a linear interpolation obtained from these data. It seems that Talys overesitimates the yield by a factor of about 2, in line with our findings with the cross sections (see Fig.1).…”

Section: Comparison With Other Production Routesmentioning

confidence: 99%

“…Tab. 2 compares the derived 52g Mn production yield determined from the nuclear reaction codes, and when available, from experimental measures [7] as well as from nuclear data evaluations [5]. We have added in the comparison also the output obtained from the ARRONAX Radionuclide Yield Calculator (RYC) [41], which is based on the TENDL library [29].…”

Section: Comparison With Other Production Routesmentioning

confidence: 99%

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Production of high purity 52gMn from natV targets with α beams at cyclotrons

Colombi

Carante

Barbaro

et al. 2020

Preprint

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BackgroundRadioisotope 52g Mn is of special interest for multimodal imaging (PET/MRI) applications and the main production route is based on proton/deuteron beams on Chromium (natural/enriched) targets. Using state-of-art nuclear reaction codes (Talys, Empire and Fluka), we perform a comparative study with the alternative 52g Mn production with the reaction nat V(α,x) 52g Mn. ResultsThis production channel, novel in the context of medical applications, provides a good source of 52g Mn, where very high radionuclidic purity can be maintained up to 3 weeks. Since nat V consists already of 99.75% 51 V , there is no need of enriched target material and the corresponding high-cost implications. The production of the main long-lived contaminants, i:e: 53 Mn and 54 Mn, is considered with care and the integral yields of the reactions are compared with the alternative production routes. Specifically, the production of the 54 Mn contaminant, which could be the most dangerous for clinical applications, turns out to be lower when compared with the natural Chromium target. ConclusionsThis channel turns out competitive with respect to the other considered production routes. The study also reveals poor accuracy of the relevant cross-section data set and indicates that better data and theoretical descriptions are needed for a precise evaluation of nat V(α,x) 52g Mn.

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Methods for producing the Mn52 isotope

Cited by 15 publications

References 5 publications

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

The innovative ^52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation

Production of high purity 52gMn from natV targets with α beams at cyclotrons

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Methods for producing the Mn52 isotope

Cited by 15 publications

References 5 publications

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

The innovative $^{52g}$Mn for PET imaging: production cross section modeling and dosimetric evaluation

The innovative 52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation

Production of high purity 52gMn from natV targets with α beams at cyclotrons

Contact Info

Product

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The innovative ^52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation