Methods for reactive oxygen species (ROS) detection in aqueous environments

Burns, Justina M.; Cooper, William J.; Ferry, John L.; King, D. Whitney; DiMento, Brian P.; McNeill, Kristopher; Miller, Christopher J.; Miller, William L.; Peake, Barrie M.; Rusak, Steven A.; Rose, Arthur W.; Waite, T. David

doi:10.1007/s00027-012-0251-x

Cited by 369 publications

(237 citation statements)

References 354 publications

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“…For acute toxicity, daphnia LC 50 was 7.99 mg L −1 , indicating that MPB was acutely toxic (1.0 < LC 50 < 10.0 mg L −1 ) for daphnia, according to the EU criteria [23]. However, for fish and green algae, MPB was classified as harmful (10.0 < LC 50 [36]. This indicates that the ECOSAR program is suitable to assess the toxicities of MPB and its transformational products.…”

Section: Structure and Aquatic Toxicity Of Mpbmentioning

confidence: 99%

“…5b, the trends of chronic toxicity to green algae and daphnia are similar to those of the corresponding acute toxicity, whereas for fish, the chronic toxicity decreased during MPB degradation. As shown in Table S1, according to the abovementioned toxicity criteria, MPB-2OH was non-harmful for green algae because both EC 50 and ChV are above 100.0 mg L −1 . However, the LC 50 and ChV were 1.17 and 0.23 mg L −1 for daphnia, and 10.91 and 2.69 mg L −1 for fish, respectively, indicating that MPB-2OH was toxic for daphnia and harmful for fish.…”

Section: Toxicity Assessmentmentioning

confidence: 99%

“…As shown in Table S1, according to the abovementioned toxicity criteria, MPB-2OH was non-harmful for green algae because both EC 50 and ChV are above 100.0 mg L −1 . However, the LC 50 and ChV were 1.17 and 0.23 mg L −1 for daphnia, and 10.91 and 2.69 mg L −1 for fish, respectively, indicating that MPB-2OH was toxic for daphnia and harmful for fish. MPB-OH, the subsequent product from MPB-2OH, was toxic to both green algae and fish; however, non-harmful for daphnia, e.g., the LC 50 and ChV were 8.51 and 0.96 mg L −1 for green algae, making it toxic ( Fig.…”

Section: Toxicity Assessmentmentioning

confidence: 99%

“…However, to green algae, chronic toxicity increased initially, and then decreased. The EC 50 and ChV of IM-O 4 were calculated to be 23.94 and 2.58 mg L −1 for green algae, and the LC 50 of BFA was calculated to be 61.61 mg L −1 for daphnia (Table S1), indicating that both IM-O 4 and BFA are harmful.…”

Section: Toxicity Assessmentmentioning

confidence: 99%

“…Therefore, • OH may play an important role in parabens degradation in natural waters, and • OH-initiated photochemical degradation of MPB may occur [49]. Generally, [ • OH] in natural waters is 10 −15 -10 −18 mol L −1 [50] and much lower than that in AOPs by 5-9 orders of magnitude. Thus, the fate of MPB in natural waters might be different from AOPs; the t 1/2 of MPB degradation was measured by varying the [ • OH] and water temperature (Table S4 and Fig.…”

Section: Fate Prediction Of Mpb In Natural Watersmentioning

confidence: 99%

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Computational consideration on advanced oxidation degradation of phenolic preservative, methylparaben, in water: mechanisms, kinetics, and toxicity assessments

Gao

Fang

et al. 2014

Journal of Hazardous Materials

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Section: Structure and Aquatic Toxicity Of Mpbmentioning

confidence: 99%

Section: Toxicity Assessmentmentioning

confidence: 99%

Section: Toxicity Assessmentmentioning

confidence: 99%

Section: Toxicity Assessmentmentioning

confidence: 99%

Section: Fate Prediction Of Mpb In Natural Watersmentioning

confidence: 99%

See 3 more Smart Citations

Computational consideration on advanced oxidation degradation of phenolic preservative, methylparaben, in water: mechanisms, kinetics, and toxicity assessments

Gao

Fang

et al. 2014

Journal of Hazardous Materials

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Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

et al. 2023

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Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting the effect of cancer immunotherapy. Pyroptosis, a lytic programmed cell-death pathway unlike apoptosis, is considered a type of immunogenic cell death (ICD) that can intensify the ICD process in tumor cells, releasing dramatically increased tumor-associated antigens and damage-associated molecular patterns to promote cancer immunotherapy. Herein, a tumor cell membrane-targeted aggregation-induced emission photosensitive dimer is found to be able to achieve highly efficient ICD under the synergistic effect of photodynamic and photothermal therapy. The photosensitive dimer can efficiently produce type-I reactive oxygen species (ROS) by photodynamic therapy in hypoxic tumor tissue, leading to pyroptosis by direct cell membrane damage, which is further reinforced by its photothermal effect. Furthermore, the enhanced ICD effect based on the dimer can completely eliminate the primary tumor on the seventh day of treatment and can also boost systemic antitumor immunity by generating immune memory, which is demonstrated by the superior antitumor therapeutic effects on both solid tumors and metastatic tumors when healing 4T1 tumor mouse models with poor immunogenicity.

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Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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Methods for reactive oxygen species (ROS) detection in aqueous environments

Cited by 369 publications

References 354 publications

Computational consideration on advanced oxidation degradation of phenolic preservative, methylparaben, in water: mechanisms, kinetics, and toxicity assessments

Computational consideration on advanced oxidation degradation of phenolic preservative, methylparaben, in water: mechanisms, kinetics, and toxicity assessments

Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

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