Methods for the Analysis of Glycated Haemoglobins: What is Being Measured?

John, W. Garry; Bullock, D G; Mackenzie, Fiona

doi:10.1111/j.1464-5491.1992.tb01708.x

Cited by 24 publications

(8 citation statements)

References 10 publications

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“…There were 18 boys and 14 girls; their median age was 11.5 (range 3.2-1 7.2) years and median duration of diabetes was 5 (range 0. [4][5][6][7][8][9][10][11] years. Venous samples were collected into a sequestrate tube and processed in the usual manner.…”

Section: Patientsmentioning

confidence: 99%

“…Twenty-five posted samples were compared with venous samples collected during the clinic from the group of children that were comparable in age (median 11.2 (range 5.3-1 9) years), sex (M 16, F 9) and duration of diabetes (median 4 (range 0. [5][6][7][8][9] years) with the other study groups. The first two studies were conducted in the summer of 1991.…”

Section: Patientsmentioning

confidence: 99%

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A Novel Capillary Collection Method for Obtaining Current Glycosylated Haemoglobin Levels in Diabetic Children

et al. 1994

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A simple method for collecting capillary blood for measurement of glycosylated haemoglobin (HbA1c) was developed that allows samples to be obtained at home and then mailed to the laboratory 2 weeks before a hospital visit. A single drop of blood is collected into a 2 ml plastic tube and sent for HbA1c assay on the Diamat HPLC system which has inter- and intra-assay coefficients of variation < 2.6 and < 1.2%, respectively. Results of simultaneously obtained venous and capillary samples in 32 diabetic children agreed well with each other. A separate study of 25 patients was performed to determine whether transport conditions affected the samples. Posted samples were compared with venous samples; again the values were in good agreement. This method is now used routinely in the diabetic clinic. Its value was determined by questionnaire in 40 children with age range 4-17 years. No family experienced difficulty collecting samples and all samples received were suitable for analysis. Children preferred this method to blood collection in the clinic as they felt it was less traumatic and more convenient. Seventy-nine percent of them understood its value in the long-term control of diabetes. In 40.5% of visits changes to management were made at the clinic due to the availability of the results.

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Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

A Novel Capillary Collection Method for Obtaining Current Glycosylated Haemoglobin Levels in Diabetic Children

et al. 1994

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“…'°However, charge dependent methods, which overestimate glycated haemoglobin concentration when the fetal haemoglobin concentration is raised, are still used by most laboratories participating in the UK national external quality assessment scheme for glycated haemoglobins. 23 The wider acceptance of measures of glycation since the early 1980s may have led to a reluctance to use the oral glucose tolerance test in diagnosing diabetes, on grounds of cost or convenience since a raised HbA1 concentration is assumed to reflect a previous significantly raised blood glucose concentration. These cases show the occasional dangers attached to that assumption.…”

Section: Importance Of Fetal Haemoglobin In Diabetesmentioning

confidence: 99%

Diagnostic confusion in diabetes with persistence of fetal haemoglobin.

Robertson¹,

Tunbridge²,

John³

et al. 1992

BMJ

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“…A standard measure of diabetic control is hemoglobin A1c (HbA1C), which corresponds to the percentage of hemoglobin that is irreversibly glycosylated . Maintenance of HbA1C levels below 7% has been associated with a decrease in microvascular complications and cardiovascular events in individuals with type 2 diabetes mellitus (T2DM).…”

mentioning

confidence: 99%

Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation

2019

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Liver transplant centers often establish hemoglobin A1c (HbA1C) criteria for candidates with type 2 diabetes mellitus (T2DM) based on data from other surgical specialties showing worse outcomes in patients with poor glycemic control. However, because of the reduced reliability of HbA1C in cirrhosis, it is unclear whether pretransplant HbA1C values are predictive of postoperative complications in liver recipients. We retrospectively examined the association between preoperative HbA1C and postoperative outcomes in 173 consecutive patients who underwent liver transplantation at the University of Cincinnati Medical Center between August 2012 and March 2015. Demographic correlates of pretransplant HbA1C included age, T2DM, native Model for End‐Stage Liver Disease, hemoglobin, serum albumin, and nonalcoholic steatohepatitis as the indication for transplantation. No association was identified between pretransplant HbA1C and most outcome measures, including survival, length of stay, reoperation or readmission rates, rejection, bacteremia, and viremia. Significant correlates of HbA1C in liver recipients with diabetes were posttransplant insulin requirement and anastomotic biliary stricture formation. On multivariate analysis, HbA1C was the sole determinant of biliary strictures, with patients in the highest quartile (HbA1C >7.3%) exhibiting a 4‐fold increased risk. Correlation of HbA1C with morning blood glucose levels was much tighter after versus before transplantation. Conclusion: Preoperative HbA1C is predictive of anastomotic biliary stricture formation and the need for insulin following liver transplantation.

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Methods for the Analysis of Glycated Haemoglobins: What is Being Measured?

Cited by 24 publications

References 10 publications

A Novel Capillary Collection Method for Obtaining Current Glycosylated Haemoglobin Levels in Diabetic Children

A Novel Capillary Collection Method for Obtaining Current Glycosylated Haemoglobin Levels in Diabetic Children

Diagnostic confusion in diabetes with persistence of fetal haemoglobin.

Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation

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