Methods for the induction of labor: efficacy and safety

Sánchez-Ramos, Luis; Levine, Lisa D.; Sciscione, Anthony; Mozurkewich, Ellen; Ramsey, Patrick S.; Adair, Charles; Kaunitz, Andrew M.; McKinney, Jordan A.

doi:10.1016/j.ajog.2023.02.009

Cited by 15 publications

(1 citation statement)

References 198 publications

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“…Standardowo stosowanie tego zabiegu u pacjentek od 38. tygodnia ciąży nie powoduje znacznych korzyści klinicznych 1,20,21 .…”

Section: Oddzielenie Dolnego Bieguna Jaja Płodowegounclassified

Methods of childbirth induction – a review of current knowledge

Kuźma,

Łokczewska-Bojar,

Kuziemkowska

et al. 2023

J Educ Health Sport

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Introduction: Pregnancy lasts 40 weeks from the first day of the last menstrual period, i. e. 280 days or 264 days from conception. It has been established that a child born between 37+0 and 41+6 weeks of gestation is a child born "on time". Unfortunately, in some cases it is necessary to terminate the pregnancy earlier, due to the condition of the pregnant woman, the baby or the approaching 42 weeks of pregnancy. Aim of the study: The aim of our study is to summarize available options for induction of childbirth. Particular attention was paid to available pharmacology and mechanical methods. The methods were compared in terms of effectiveness, possible complications and side effects. Materials and methods: A review of the current literature was made in the accessible PubMed and Google Scholar database, using the keywords: „birth induction”, „Cook’s catether”, „prostaglandin and oxitocine induction”, „amniotomy”, „membran stripping”. Conclusions: There are several ways to induce childbirth, which are used depending on current state of pregnacy. The availability of both pharmacotherapy and mechanical methods, allows the initiation of labor and termination of pregnancy by natural forces, in most cases avoiding the need to terminate the pregnancy by caesarean section.

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“…Standardowo stosowanie tego zabiegu u pacjentek od 38. tygodnia ciąży nie powoduje znacznych korzyści klinicznych 1,20,21 .…”

Section: Oddzielenie Dolnego Bieguna Jaja Płodowegounclassified

Methods of childbirth induction – a review of current knowledge

Kuźma,

Łokczewska-Bojar,

Kuziemkowska

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

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4‐Aza Cyclopentenone Prostaglandin Analogues: Synthesis and NF‐κB Inhibitory Activities

Doherty,

Conway,

Leveau

et al. 2024

ChemMedChem

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Inspired by the cyclopentenone family of prostaglandins, a series of 4‐aza, cross‐conjugated cyclopentenones is described. Synthesised from N‐protected (4R)‐aza‐cyclopentenone 5, the exocyclic alkene was installed using a modified Baylis‐Hillman type aldol reaction, whereby carbon‐carbon bond formation is accompanied by dehydration. In this manner octanal and octenal, for example, can be introduced to mimic the w‐group present in the natural prostaglandins. Similarly, a focused range of alternative substituents were introduced using different aldehydes and ketones. The presence of the tert‐butyloxycarbonyl (Boc) group on the 4‐amino‐cyclopentenone substituent enabled subsequent derivatisation and various electrophiles were successfully incorporated. The ability of the family of 4‐amino functionalised cross‐conjugated cyclopentenones to block activation of nuclear factor‐kappa B (NF‐kB) was studied and compared with the natural prostanoid, D12,14‐15‐deoxy‐PGJ2 (2). Thereafter, the synthesis of a series of thiol adducts from these compounds were prepared and similarly evaluated biologically. The adducts showed comparable and, on occasion, more potent inhibition of NF‐kB than their cyclopentenone precursors and generally demonstrated diminished cytotoxicity. For example, cross‐conjugated dieneone 12 inhibited the activation of NF‐kB with an IC50 value of 6.2 mM, whereas its endocyclic N‐Boc (27) and N‐acetyl (28) cysteine adducts blocked NF‐kB activity with values of 1.0 and 8.0 mM respectively.

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Safety of the use of dinoprostone gel and vaginal insert for induction of labor: A multicenter retrospective cohort study

Di Tommaso,

Pellegrini,

Ammar

et al. 2024

Intl J Gynecology & Obste

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ObjectiveTo assess adverse obstetric and neonatal outcomes associated with the use of dinoprostone for induction of labor, with particular attention on categories for which caution is recommended by the Italian Medicines Agency and the European Medicine Agency.MethodsA retrospective multicenter observational study was conducted on a population of 1687 patients undergoing induction of labor with vaginal dinoprostone (gel or insert) between August 2019 and June 2022. Patients were subdivided based on maternal age, gestational age, and obstetric disorders. Data regarding the mode of delivery, the incidence of tachysystole, and the obstetric and perinatal outcomes were collected.ResultsThe main adverse event associated with the use of dinoprostone was tachysystole. However, tachysystole was not associated with an increased risk of cesarean section (CS), neonatal intensive care (NICU) admission, low 1‐min Apgar, or umbilical cord acidosis. Maternal age greater than 35 years, gestational age greater than 40 weeks, and obstetric disorders were not associated with an increased rate of tachysystole, NICU admission, low 1‐ and 5‐min Apgar scores, and cord acidosis. The only associated adverse outcomes in those categories were postpartum hemorrhage with age greater than 35 years and tachysystole with gestational diabetes mellitus and hypertensive disorders. Not a single case of severe outcome (disseminated intravascular coagulation, uterine rupture, maternal and fetal death) was reported in the cohort.ConclusionProviding there is adequate maternal and fetal surveillance, in an inpatient setting, dinoprostone could be safely administered for the induction of labor and considered appropriate in high‐risk pregnancies. Tachysystole can be self‐identified by the patient and effectively managed.

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Methods for the induction of labor: efficacy and safety

Cited by 15 publications

References 198 publications

Methods of childbirth induction – a review of current knowledge

Methods of childbirth induction – a review of current knowledge

4‐Aza Cyclopentenone Prostaglandin Analogues: Synthesis and NF‐κB Inhibitory Activities

Safety of the use of dinoprostone gel and vaginal insert for induction of labor: A multicenter retrospective cohort study

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