Methods for the synthesis of α,β-unsaturated trifluoromethyl ketones and their use in organic synthesis

Efficient route to 6-CF3-substituted nicotinic acid derivatives

“…NMR spectra were recorded on Varian VXR-400 and Bruker AM 400C spectrometers in CDCl 3 with TMS as an internal standard and Me 2 SO-d 6 . The IR spectra were obtained with UR-20 spectrometer.…”

“…In this aspect methods for synthesis of trifluoromethyl derivatives of pyridine can serve as very useful tool for modification of existing drugs and for obtaining novel drug candidates. One of the useful methods for synthesis of CF 3 -derivatives of heterocyclic compounds is application of a,bunsaturated trifluoromethylketones as building blocks [6].…”

Synthesis of novel β-dialkylamino-α,β-unsaturated trifluoromethylketones containing cyclobutene fragment and their reactions with organolithium and Grignard reagents

“…IR (mineral oil) 3425, 3001, , 1157 6,137.2,126.7,126.2,125.4,124.0 (q,J 286 Hz), 76.1 (q, J 30 Hz), 68. 2,59.0,31.4,31.0,21.9. 4.3.2.…”

“…Found: C, 61.92; H, 5.60; F, 21.09. C 14 2,134.3,129.6,128.9,126.8,124.8 (q,J 290 Hz),77.4 (q,J 30 Hz),68.4,59.7,32.5,31.7,21.1. …”

New derivatives of trifluoroacetyl acetaldehyde and trifluoroaldol

“…1) [7,8], which are prepared easily by trifluoroacetylation of corresponding alkylvinyl ethers [9,10]. This route to the b-alkoxyvinyl trifluoromethyl ketones becomes more complicated when it is necessary to use non-commercial alkyl vinyl ethers, for example with chiral alkoxy group such as a-phenylethoxy.…”