Human consumption of marine organisms that have been contaminated by ocean disposal of municipal sewage sludges may pose significant health risks. Previous models of ocean dumping health risk, however, have failed to assess uncertainties associated with model parameters. This failure has resulted in risk assessments that may be misleading to policymakers. Uncertainties regarding contaminant bioaccumulation, commercial fish landings and seafood consumption were incorporated into a model of carcinogenic health risk for two materials found in municipal sewage sludges, dichlorodiphenyltrichloroethane and metabolites (DDT-R) and polychlorinated biphenyls (PCBs). Iterative Latin hypercube simulation was employed to generate probability distributions of health risks. Results indicate that parameter variability and uncertainty, particularly in bioaccumulation models, can lead to a several-orders-of-magnitude range in estimated risk values. This distributional range straddles current risk-management thresholds, suggesting that ocean disposal of municipal sludges may, indeed, pose substantial health risks to seafood consumers under certain sets of conditions and assumptions. Moreover, if not explicitly considered in risk models, uncertainty can lead to errors in risk-based decision making.